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Plant WRKY DNA-binding transcription factors are involved in plant responses to biotic …


Biology Articles » Botany » Plant Pathology » Roles of Arabidopsis WRKY3 and WRKY4 Transcription Factors in Plant Responses to Pathogens » Conclusion

Conclusion
- Roles of Arabidopsis WRKY3 and WRKY4 Transcription Factors in Plant Responses to Pathogens

Crosstalk between defense signaling pathways is an important mechanism for regulating defense mechanisms against different types of microbial pathogens. Although genes capable of regulating the crosstalk have been reported, the underlying mechanisms have not been clearly understood. Identification of a number of WRKY transcription factors that affect plant resistance in opposite ways to different types of microbial pathogens suggest that the regulation of the crosstalk between these defense signaling pathways occurs at the transcription level. For example, some of these WRKY transcription factors may regulate the crosstalk by activating expression of JA/ET-regulated genes but repressing SA-regulated genes. Such direct and opposite roles in regulation of gene expression would require these WRKY transcription factors acting as transcriptional activators or repressors in a gene-specific manner. Alternatively, the WRKY transcription factors regulate the crosstalk by activating expression of genes associated with JA/ET-mediated signaling pathways, including some encoding transcriptional repressor that suppress SA-regulated gene expression. Further studies on the transcriptional activation/repression activities and direct transcriptional targets of the WRKY proteins could generate important insights into the molecular network of complex plant defense responses to different types of microbial pathogens.

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