Role of reaction kinetics and mass transport in glucose sensing with nanopillar array electrodes
Venkataramani Anandan1, Xiaoling Yang1, Euihyeon Kim2, Yeswanth L Rao1 and Guigen Zhang1,3,4
1Micro/Nano Bioengineering Lab, Department of Biological and Agricultural Engineering, The University of Georgia, Athens, GA 30602, USA
2Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA 30332-0535, USA
3Nanoscale Science and Engineering Center, The University of Georgia, Athens, GA 30602, USA
4Faculty of Engineering, The University of Georgia, Athens, GA 30602, USA
The use of nanopillar array electrodes (NAEs) for biosensor applications was explored using a combined experimental and simulation approach to characterize the role of reaction kinetics and mass transport in glucose detection with NAEs. Thin gold electrodes with arrays of vertically standing gold nanopillars were fabricated and their amperometric current responses were measured under bare and functionalized conditions. Results show that the sensing performances of both the bare and functionalized NAEs were affected not only by the presence and variation of the nanoscale structures on the electrodes but also by the reaction kinetics and mass transport of the analyte species involved. These results will shed new light for enhancing the performance of nanostructure based biosensors.
Journal of Biological Engineering 2007, 1:5.This is an Open Access article distributed under the terms of the Creative Commons Attribution License.