Genome-wide analysis of sequence divergence patterns in 12 024 human–mouse orthologous pairs reveals

• Abstract
• Introduction
• Materials and methods
• Results
• Discussion
• References
• Figures
• Tables

Biology Articles » Biochemistry » Nucleic Acid Biochemistry » Reverse Polarization in Amino acid and Nucleotide Substitution Patterns Between Human–Mouse Orthologs of Two Compositional Extrema » Figures

Figures

- Reverse Polarization in Amino acid and Nucleotide Substitution Patterns Between Human–Mouse Orthologs of Two Compositional Extrema

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Figure 1. Scatter plot of (A) overall GC content (%) and (B) GC content at third codon sites (%) of 12 024 orthologous genes of human and mouse with their correlation coefficient values.

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Figure 2. Left panel: distribution of GC content at first and second codon positions among human (blue) and mouse (red) orthologous genes for (A) high-, (C) medium-, and (E) low-GC group with their normal distributions. Right panel: distribution of GC content at third codon position among human and mouse orthologous genes for (B) high-, (D) medium-, and (F) low-GC group with their normal distributions.

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Figure 3. Positions of orthologous gene pairs between human and mouse along the first two identical principal axes generated by COA on RSCU values of (A) 3896 genes from high-GC group, (B) 3960 genes from medium-GC group, and (C) 4168 genes from low-GC group. The filled quadrangle and open quadrangle represent genes from mouse and human orthologous genes, respectively.

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