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The existing dogma that the former term ovarian "germinal epithelium" …


Biology Articles » Reproductive Biology » Reinstatement of "germinal epithelium" of the ovary » Background

Background
- Reinstatement of "germinal epithelium" of the ovary

Unlike the avian ovary, where the follicles containing a large yolky egg look like a cluster of yellowish grapes, the human ovary is solid in structure, amygdaloid in shape, grayish white in color, and the follicles are usually invisible through the surface. Since the intraovarian follicle was firstly identified by Reinier De Graaf in 1672 [1], the origin of human oocyte has been disputed. Two opposing views have been known regarding the source of oocytes: (1) that they arise in the yolk sac [2-5], or (2) that they arise in the gonadal tissue itself [6-11]. The former view had gotten public consensus until the astonishing works by Bukovsky et al. on the capability of ovarian covering tissue to produce new oocytes in adult human females were published [12-15].

A study of the histogenesis of ovarian components is essential to understand the oncogenesis of ovarian neoplasms. Since the ovarian covering tissue has now been revealed to have oogenic capability, the surface epithelium might be accountable as a source of germ cell tumors and sex cord-stromal cell tumors, as well as neoplasms exhibiting the müllerian histology.


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