Nipah virus (NiV) is an emerging paramyxovirus distinguished by its ability to …

• Abstract
• Background
• Results
• Discussion
• Conclusion
• Methods
• Competing interests
• References
• Figures

Biology Articles » Virology » Quantitative analysis of Nipah virus proteins released as virus-like particles reveals central role for the matrix protein » Conclusion

Conclusion

- Quantitative analysis of Nipah virus proteins released as virus-like particles reveals central role for the matrix protein

Nipah Virus-like particles can be produced by recombinant gene expression. The matrix, fusion, and attachment proteins each possess some budding ability of their own; however, the matrix protein appears to play a central role in virus particle assembly and release from expressing cells. The system developed here along with the present findings will help facilitate studies on NiV morphogenesis in greater detail, and provide a platform for exploring the nature and role of potential host factors in the virus budding process. Importantly, the VLP system detailed here also allows for the examination of recombinant particle assembly and release outside high-level biological containment.