table of contents 
To compare the frequency of Y-chromosome microdeletions in Japanese and African azoospermic …
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Table 1
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STS markers of the 7 infertile men with Y chromosome deletions.
|
STS
|
Region
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|
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|
|
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Markers
|
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1.1
|
1.2
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1.5
|
1.6
|
1.7
|
1.8
|
1.9
|
|
sY14
|
|
+
|
+
|
+
|
+
|
+
|
+
|
+
|
sY18
|
|
+
|
+
|
+
|
+
|
+
|
+
|
+
|
sY78
|
|
+
|
+
|
+
|
+
|
+
|
+
|
+
|
sY81
|
AZFa
|
-
|
-
|
+
|
+
|
+
|
+
|
+
|
sY83
|
|
-
|
-
|
+
|
+
|
+
|
+
|
+
|
sY85
|
|
-
|
-
|
+
|
+
|
+
|
+
|
+
|
sY84
|
|
-
|
-
|
+
|
+
|
+
|
+
|
+
|
sY90
|
|
-
|
-
|
+
|
+
|
+
|
+
|
+
|
sY100
|
AZFb
|
+
|
-
|
+
|
+
|
+
|
+
|
+
|
sY131
|
|
+
|
-
|
+
|
+
|
+
|
+
|
+
|
sY134
|
|
+
|
-
|
+
|
+
|
+
|
+
|
+
|
sY139
|
|
+
|
-
|
+
|
+
|
+
|
+
|
+
|
sY145
|
|
+
|
-
|
+
|
+
|
+
|
+
|
+
|
sY143
|
|
+
|
+
|
+
|
+
|
+
|
+
|
|
sY153
|
AZFc
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY147
|
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY156
|
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY149
|
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY254
|
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY157
|
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY202
|
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY243
|
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
sY158
|
|
+
|
-
|
+
|
+
|
+
|
+
|
+
|
sY159
|
|
+
|
-
|
+
|
+
|
+
|
+
|
+
|
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Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9 doi:10.1186/1743-1050-2-9
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Table 2
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Findings in 7 infertile men with Y chromosome microdeletion
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Patient Nos.
|
|
|
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1.1
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1.2
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1.5
|
1.6
|
1.7
|
1.8
|
1.9
|
|
Left/right testis volume (ml)
|
9&14
|
12&14
|
14&15
|
13&15
|
9&8
|
13&14
|
8&7
|
sperm conc (× 106 /ml)
|
0
|
0
|
0
|
0.9
|
0.6
|
1.5
|
0
|
Deleted AZF regions
|
a
|
a, b, c
|
c
|
c
|
c
|
c
|
c
|
FSH (U/ml)
|
29.5
|
31.3
|
10.3
|
11.6
|
9.1
|
12.7
|
14.3
|
Testicular histology
|
SCOS
|
SCOS
|
MA
|
ND
|
ND
|
ND
|
MA
|
Sperm testicular recovery
|
0
|
0
|
+
|
ND
|
ND
|
ND
|
+
|
|
ND = Not done; MA = Maturation Arrest; SCOS = Sertoli cell only syndrome
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Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9 doi:10.1186/1743-1050-2-9
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Table 3
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Results of the various parameters of ejaculate sperm cycles in patients with AZFc region Y-deleted and Y-Intact chromosomes.
|
|
AZFc region
|
|
Y-deleted Chromosome
|
Y-Intact Chromosome
|
Significance
|
|
Total No. Patients
|
5
|
11
|
|
Total No. Cycles
|
8
|
19
|
|
Female Age (mean)
|
30.9 ± 6.2
|
30.4 ± 5.7
|
NS
|
Duration of infertility in years (mean)
|
4.9 ± 3.1(2–10)
|
4.4 ± 2.7(2–6)
|
|
Peak E2 pg/dl (mean)
|
3613 ± 1876
|
3785 ± 1543
|
NS
|
Embryos Transferred (average))
|
2.7(2–3)
|
2.8 (2–4)
|
NS
|
Sperm Normal Morphology (%)
|
2.3 ± 0.5%
|
3.4 ± 0.7
|
NS
|
Sperm Concentration (× 106/mL)
|
1.5 ± 1.1
|
4.3 ± 1.2
|
p |
Motility (%)
|
35 ± 14.7
|
41 ± 11.4
|
NS
|
|
Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9 doi:10.1186/1743-1050-2-9
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Table 4
|
ICSI attempts in 8 cycles with Y-chromosome microdeletions and 19 cycles without microdeletions.
|
|
Y-deleted
|
Y-Intact
|
|
|
|
Chromosome
|
Chromosome
|
Significance
|
|
No cycles with ejaculated sperm
|
6
|
19
|
NS
|
No. cycles with Testicular sperm
|
2
|
0
|
|
Total No. oocytes
|
108
|
269
|
NS
|
Average No.oocytes (n)
|
13.5 ± 2.7
|
12.8 ± 3.5
|
NS
|
Fertilization rate(%)
|
60.1 ± 17.9%
|
71.6 ± 15.7%
|
NS
|
Cleavage rate (%)
|
87.6 ± 14.5
|
85.1 ± 9.4
|
NS
|
Embryo grade 1 & II on day 3/cleaved embryos
|
51.70%
|
59.60%
|
NS
|
≥6 cells embryos on day 3/cleaved embryos (%)
|
75.00%
|
72.9
|
NS
|
Blastocyts on day 5&6 /cleaved embryos (%)
|
50.00%
|
53.40%
|
NS
|
Canceled cycle(s)
|
1
|
0
|
NS
|
Average mixed embryo & blastocyst ET
|
2.7 ± 0.5
|
2.8 ± 0.9
|
NS
|
Pregnancy
|
3 (37.5%)
|
9 (42.9)
|
NS
|
Implantation rate
|
13.5
|
16.9
|
NS
|
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Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9 doi:10.1186/1743-1050-2-9
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