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To compare the frequency of Y-chromosome microdeletions in Japanese and African azoospermic …


Biology Articles » Reproductive Biology » Prospective assessment of Y-chromosome microdeletions and reproductive outcomes among infertile couples of Japanese and African origin » Tables

Tables
- Prospective assessment of Y-chromosome microdeletions and reproductive outcomes among infertile couples of Japanese and African origin

Table 1

STS markers of the 7 infertile men with Y chromosome deletions.

STS
Region







Markers

1.1
1.2
1.5
1.6
1.7
1.8
1.9
sY14

+
+
+
+
+
+
+
sY18

+
+
+
+
+
+
+
sY78

+
+
+
+
+
+
+
sY81
AZFa
-
-
+
+
+
+
+
sY83

-
-
+
+
+
+
+
sY85

-
-
+
+
+
+
+
sY84

-
-
+
+
+
+
+
sY90

-
-
+
+
+
+
+
sY100
AZFb
+
-
+
+
+
+
+
sY131

+
-
+
+
+
+
+
sY134

+
-
+
+
+
+
+
sY139

+
-
+
+
+
+
+
sY145

+
-
+
+
+
+
+
sY143

+
+
+
+
+
+

sY153
AZFc
+
-
-
-
-
-
-
sY147

+
-
-
-
-
-
-
sY156

+
-
-
-
-
-
-
sY149

+
-
-
-
-
-
-
sY254

+
-
-
-
-
-
-
sY157

+
-
-
-
-
-
-
sY202

+
-
-
-
-
-
-
sY243

+
-
-
-
-
-
-
sY158

+
-
+
+
+
+
+
sY159

+
-
+
+
+
+
+

Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9   doi:10.1186/1743-1050-2-9

Table 2

Findings in 7 infertile men with Y chromosome microdeletion


Patient Nos.


1.1
1.2
1.5
1.6
1.7
1.8
1.9
Left/right testis volume (ml)
9&14
12&14
14&15
13&15
9&8
13&14
8&7
sperm conc (× 106 /ml)
0
0
0
0.9
0.6
1.5
0
Deleted AZF regions
a
a, b, c
c
c
c
c
c
FSH (U/ml)
29.5
31.3
10.3
11.6
9.1
12.7
14.3
Testicular histology
SCOS
SCOS
MA
ND
ND
ND
MA
Sperm testicular recovery
0
0
+
ND
ND
ND
+

ND = Not done; MA = Maturation Arrest; SCOS = Sertoli cell only syndrome

Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9   doi:10.1186/1743-1050-2-9

Table 3

Results of the various parameters of ejaculate sperm cycles in patients with AZFc region Y-deleted and Y-Intact chromosomes.


AZFc region

Y-deleted Chromosome
Y-Intact Chromosome
Significance
Total No. Patients
5
11

Total No. Cycles
8
19

Female Age (mean)
30.9 ± 6.2
30.4 ± 5.7
NS
Duration of infertility in years (mean)
4.9 ± 3.1(2–10)
4.4 ± 2.7(2–6)

Peak E2 pg/dl (mean)
3613 ± 1876
3785 ± 1543
NS
Embryos Transferred (average))
2.7(2–3)
2.8 (2–4)
NS
Sperm Normal Morphology (%)
2.3 ± 0.5%
3.4 ± 0.7
NS
Sperm Concentration (× 106/mL)
1.5 ± 1.1
4.3 ± 1.2
p
Motility (%)
35 ± 14.7
41 ± 11.4
NS

Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9   doi:10.1186/1743-1050-2-9

Table 4

ICSI attempts in 8 cycles with Y-chromosome microdeletions and 19 cycles without microdeletions.


Y-deleted
Y-Intact


Chromosome
Chromosome
Significance
No cycles with ejaculated sperm
6
19
NS
No. cycles with Testicular sperm
2
0

Total No. oocytes
108
269
NS
Average No.oocytes (n)
13.5 ± 2.7
12.8 ± 3.5
NS
Fertilization rate(%)
60.1 ± 17.9%
71.6 ± 15.7%
NS
Cleavage rate (%)
87.6 ± 14.5
85.1 ± 9.4
NS
Embryo grade 1 & II on day 3/cleaved embryos
51.70%
59.60%
NS
≥6 cells embryos on day 3/cleaved embryos (%)
75.00%
72.9
NS
Blastocyts on day 5&6 /cleaved embryos (%)
50.00%
53.40%
NS
Canceled cycle(s)
1
0
NS
Average mixed embryo & blastocyst ET
2.7 ± 0.5
2.8 ± 0.9
NS
Pregnancy
3 (37.5%)
9 (42.9)
NS
Implantation rate
13.5
16.9
NS

Kihaile et al. Journal of Experimental & Clinical Assisted Reproduction 2005 2:9   doi:10.1186/1743-1050-2-9


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