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Pre-Diagnostic Circulating Vitamin D Concentration May Possibly Lower the Risk of Colon Cancer Based on a Cohort Study in Western European Population
Summary by Vicki Mozo
Vitamin D can be obtained both by dietary supplementary and by endogenous synthesis as stimulated by sun exposure. This vitamin plays a key role in maintaining calcium homeostasis and bone metabolism. To date, scientists are seeing the potentiality of Vitamin D in treating colon cancers since it is found to play a role in the synthesis of an active hormone by both normal and neoplastic colon cells. In order to provide more founding evidence, Jenab and colleagues conducted a nested case-control study that analyzed the relationship of pre-diagnostic 25-(OH)D concentration and dietary intakes of vitamin D and calcium with colorectal cancer risk in Western European population. Based on the results, they found a strong inverse linear dose-response association between circulating 25-(OH)D concentration and colon cancer risk (P for trend <0.001), suggesting its potential capability to lower colon cancer risk in Western European population.
Source: Mazda Jenab, et al., "Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study", British Medical Journal, January 21, 2010.
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