A genome-comparison strategy to identifying nuclear gene markers for phylogenetic inference and …

• Abstract
• Background
• Results
• Discussion
• Conclusion
• Methods
• References
• Table 1
• Table 2
• Figures

We developed a genome-based approach to identify nuclear gene markers for phylogeny inference that are single-copy, contain large exons, and are conserved across extensive taxonomic distances. We show that our approach has practical value through direct experimentation on a representative sample of ray-finned fish, the largest vertebrate clade in need of phylogenetic resolution. The same approach, however, could be applied to other groups of organisms as long as two or more complete genome sequences are available. This research may have important implications for assembling the tree of life.