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Biology Articles » Bioinformatics » Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource

Abstract
- Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource

Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource

Elliot J. Lefkowitz*, Chris Upton1, Shankar S. Changayil, Charles Buck2, Paula Traktman3 and R. Mark L. Buller4

Department of Microbiology, University of Alabama at Birmingham, BBRB 276/11; 1530 3rd Avenue S., Birmingham, AL 35294-2170, USA, 1 Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada V8W 2Y2, 2 Virology Collection, ATCC, Manassas, VA 20108, USA, 3 Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Room 273–BSB, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA and 4 Department of Molecular Microbiology and Immunology, St Louis University Health Sciences Center, 1402 South Grand Boulevard, St Louis, MO 63104, USA

Abstract

The Poxvirus Bioinformatics Resource Center (PBRC) has beenestablished to provide informational and analytical resourcesto the scientific community to aid research directed at providinga better understanding of the Poxviridae family of viruses.The PBRC was specifically established as the result of the concernthat variola virus, the causative agent of smallpox, as wellas related viruses, might be utilized as biological weapons.In addition, the PBRC supports research on poxviruses that mightbe considered new and emerging infectious agents such as monkeypoxvirus. The PBRC consists of a relational database and web applicationthat supports the data storage, annotation, analysis and informationexchange goals of the project. The current release consistsof over 35 complete genomic sequences of various genera, speciesand strains of viruses from the Poxviridae family. Sequenceand annotation information for these viruses has been obtainedfrom sequences publicly available from GenBank as well as sequencesnot yet deposited in GenBank that have been obtained from ongoingsequencing projects. In addition to sequence data, the PBRCprovides comprehensive annotation and curation of virus genes;analytical tools to aid in the understanding of the availablesequence data, including tools for the comparative analysisof different virus isolates; and visualization tools to helpbetter display the results of various analyses. The PBRC representsthe initial development of what will become a more comprehensiveViral Bioinformatics Resource Center for Biodefense that willbe one of the National Institute of Allergy and Infectious Diseases'‘Bioinformatics Resource Centers for Biodefense and Emergingor Re-Emerging Infectious Diseases’. The PBRC websiteis available at http://www.poxvirus.org.


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