An approach that displays strengths of statistical associations at a glance, and …

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Biology Articles » Genetics » Classical Genetics » Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses » Conclusion

Conclusion

- Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses

The PGA grid provides a simple visual method for displaying a large number of results, potentially reduces the problem of publication bias, and simplifies the task of summarizing large-scale association studies.


Abbreviations

LVM = left ventricular mass; LVID = left ventricular internal diameter at end diastole; LVWT = sum of septal and left ventricular posterior wall thickness; FS = left ventricular fractional shortening; AoR = aortic root diameter; LA = left atrial anteroposterior dimension. M = men only; F = women only; MF = men and women.


Authors' contributions

Daniel Levy: Conception of the display grid, drafting of paper, revisions to manuscript

Steven R. DePalma: Development of source code for display grid, revisions to manuscript

Emelia J. Benjamin: Conception of the display grid, revisions to manuscript

Christopher J. O'Donnell: Conception of the display grid, revisions to manuscript

Helen Parise: Statistical analyses for incorporation into display grid

Joel N. Hirschhorn: Conception of the display grid, revisions to manuscript

Ramachandran S. Vasan: Conception of the display grid, revisions to manuscript

Seigo Izumo: Principal investigator of CardioGenomics, funding of the project

Martin G. Larson: Conception of the display grid, development of statistical methods, revisions to manuscript


Acknowledgements

The Framingham Heart Study is funded by NIH/NHLBI contract N01-HC-25195. CardioGenomics is funded by the National Institutes of Health Program for Genomic Applications (PGA).