Login

Join for Free!
118322 members
table of contents table of contents

The discovery that peptide nucleic acids (PNA) mimic DNA and RNA by …


Biology Articles » Biochemistry » Nucleic Acid Biochemistry » Peptide nucleic acid–DNA duplexes: Long range hole migration from an internally linked anthraquinone » Conclusion

Conclusion
- Peptide nucleic acid–DNA duplexes: Long range hole migration from an internally linked anthraquinone

The results described above illustrate the exciting potential of PNA. In this case, it provides a tool for probing long range electron transfer through stacked π-electron systems as well as for the photomodification of complementary DNA strands. The ability to cleave DNA in PNA/DNA hybrids by the same mechanisms that operate in DNA/DNA duplexes is a further demonstration of the remarkable ability of PNA to mimic DNA. Although there are reports of the use of PNA–nuclease conjugates for the site-specific cleavage of double-stranded DNA (26, 39), these experiments provide the first example in which PNA cleaves single-stranded DNA targets. Extension of these studies to electron transport within PNA/PNA duplexes and PNA2/DNA triplexes is planned as are experiments that will assess the ability of the PNA strand to trap oxidative damage. The ease of synthesizing internally modified PNA, the stability of the resulting hybrid duplexes, and their ability to mimic the reactivity of duplex DNA should contribute to the growing application of PNA in chemistry, biochemistry, and medicine.

rating: 5.00 from 1 votes | updated on: 25 Sep 2008 | views: 6223 |

Rate article:







excellent!bad…