Whole saliva is a combination of gingival crevicular fluid, which has a composition similar to serum, and fluid released from salivary glands, of which the parotid, submandibular and sublingual are the three major sources. 1
The components of saliva are water, proteins, electrolytes, organic molecules secreted from salivary glands, blood, microbes, epithelial lining cells, extrinsic factors and some additional fluids. The most commonly used laboratory diagnostic procedures involve the analysis of the cellular and chemical constituents of blood. Other biologic fluids are utilized for diagnosis of disease, and saliva offers some distinctive advantages. Whole saliva can be collected non-invasively, and by individuals with limited training. In recent years saliva has attracted much attention, in particular among people interested in the determination of drug concentrations. This suggests that saliva might be substituted for plasma in the areas of pharmacokentic studies and drug monitoring because of the growing interest in non-invasive procedure.