It is concluded that 1) cis isomer forms of lycopene are more bioavailable than is all-trans-lycopene, 2) lycopene accumulation in some tissues is inversely related to androgen status and appears to be inversely related to energy intake, and that 3) tomato carotenoids differentially distribute in tissues of F344 rats. These results clearly demonstrate that all tomato carotenoids cannot be assumed to be absorbed and metabolized the same. Moreover, their absorption and metabolism is affected by hormonal status of the host and perhaps the overall redox state of the tissue.
1 Presented as part of the conference "Promises and Perils of Lycopene/Tomato Supplementation and Cancer Prevention," February 17–18, 2005, Bethesda, MD. This conference was sponsored by the Division of Cancer Prevention, Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS); Office of Dietary Supplements (ODS), NIH, DHHS; and the Agricultural Research Services (ARS), USDA. Guest editors for the supplement publication were Cindy D. Davis, NCI, NIH; Johanna Dwyer, ODS, NIH; and Beverly A. Clevidence, ARS, USDA.
2 Work described in this paper was supported in part by grants from NIH/NCI, USDA/IFAFS, and AICR.