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The nuclear receptor superfamily describes a related but diverse array of transcription …


Biology Articles » Biochemistry » Nuclear Receptor Minireview Series » Figure

Figure
- Nuclear Receptor Minireview Series

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Fig. 1.   Structure/function organization of nuclear receptors. The six domains (A-F) of nuclear receptors comprise regions of conserved function and sequence. All of the nuclear receptors contain a central DBD (region C), which is the most highly conserved domain and includes two zinc finger modules. A LBD (region E) is contained in the C-terminal half of the receptor. Situated between the DBD and LBD is a variable length hinge domain (region D), and variable N-terminal region (A/B) contains ampF-I activation function. Most receptors also contain a variable length C-terminal region F, the function of which is poorly understood. Many members of the nuclear receptor family form homo- or heterodimers, and amino acid sequences important for dimerization are contained within the DBD and LBD.

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Source: J. Biol. Chem., Vol. 276, Issue 40, 36863-36864, October 5, 2001.


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