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The authors present the first in vivo report of the effects of …


Biology Articles » Neurobiology » Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat » Results

Results
- Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat

To evaluate recovery of erectile function, the increase in maximal intracavernous pressure (which correlates to penile rigidity in men) was measured (Figure 1). Erectile dysfunction was not observed in the uninjured control group, which served to establish a baseline normal erectile response to stimulation. The mean maximal intracavernous pressure [ICP] increase observed was 117.5 ± 7.3 cmH2O. The blinded control group, which was treated with albumin only, demonstrated a significant reduction for increased ICP of 40.0 ± 6.3 cmH2O, consistent with a state of erectile dysfunction. Neurturin facilitated the preservation of erectile function, with a mean ICP increase of 55%. The increase of 62.0 ± 9.2 cmH2O was statistically significant (p 1). No statistically significant differences were observed between all groups for peak aortic blood pressure or weight gain. There were no animal deaths or incomplete treatments in this study.


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