Adult stem cell therapy, the holy grail of stem cell research, is already advanced for the treatment of some corneal conditions
However, understanding the cellular mechanisms underpinning these
surgical interventions requires a better understanding of LSC function
and corneal maintenance from well-characterised animal models as well
as human tissues. In particular, tissue ageing and its implications for
adult stem cells and their niches needs further study. Here, analysis
of age-related changes implies that LSC function declines with age.
Together with evidence from other systems, linking stem cell
deterioration to the ageing process
], this is likely to encourage investigations of how LSCs and the limbal niche change with age.