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Investigated if carcinogen defense (phase 2) enzymes could be induced in the prostate …


Biology Articles » Biochemistry » Enzymology » Modest induction of phase 2 enzyme activity in the F-344 rat prostate » Tables

Tables
- Modest induction of phase 2 enzyme activity in the F-344 rat prostate

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Table 1
Final body weight and relative organ weights of male control and inducer treated F344 rats

Sulforaphane
BNF
Curcumin
DMF
Control
Number
8
10
10
10
10
Final body weight (g)
177.5 ± 10.35 *
190.3 ± 12.56
184.4 ± 13.59
190.2 ± 15.65
195.8 ± 8.52
Liver (%)
4.13 ± 0.22
4.84 ± 0.27
4.60 ± 0.22
4.71 ± 0.37
4.96 ± 0.22
Kidney (%)
0.86 ± 0.07
0.97 ± 0.04
0.91 ± 0.04
0.93 ± 0.04
0.88 ± 0.04
Prostate (%)
0.15 ± 0.02
0.17 ± 0.04
0.15 ± 0.03
0.15 ± 0.03
0.17 ± 0.03
Bladder (%)
0.03 ± 0.01
0.02 ± 0.01
0.03 ± 0.01
0.03 ± 0.01
0.02 ± 0.01
Data are mean ± SEM values. * = P

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Table 2
Mean specific activity of NQO1 in nmol/min/mg of protein (Ratio of the treated/control enzyme specific activities, 95% Confidence Intervals)

Sulforaphane
BNF
Curcumin
DMF
Control
Liver
69 (2.5, 2.2–2.9)*
43 (1.6, 1.5–1.7)*
34 (1.2, 0.99–1.6)
32 (1.2, 1.04–1.3)*
27
Kidney
41 (2.5, 2.2–2.9)*
26 (1.6, 1.5–1.7)*
20 (1.2, 0.99–1.6)
19 (1.2, 1.04–1.3)*
16
Prostate
103 (1.6, 1.4–1.9)*
80 (1.3, 1.1–1.5)*
72 (1.2, 0.95–1.4)
65 (1.04, 0.85–1.3)
63
Bladder
26 (4.4, 4.2–4.7)*
9.0 (1.5,1.2–1.8)*
10 (1.8, 1.4–2.1)*
10 (1.8. 1.4–2.2)*
6.0
Data are mean values of 8–10 animals in each group
* = P

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Table 3
Mean specific activity of Total GST in nmol/min/mg of protein (Ratio of the treated/control enzyme specific activities, 95% Confidence Intervals)

Sulforaphane
BNF
Curcumin
DMF
Control
Liver
956 (1.6, 1.4–1.7)*
815 (1.4, 1.2–1.5)*
739 (1.2, 1.1–1.4)*
679 (1.1, 1.03–1.2)*
602
Kidney
92.5 (1.2, 1.0–1.3)
80 (1.0, 0.77–1.3)
65 (0.81, 0.67–1.0)
89 (1.1, 0.96–1.3)
81
Prostate
6.7 (1.2, 1.1–1.5)*
5.7 (1.06, 1.0–1.1)
6.9 (1.3,1.2–1.4)*
7.0 (1.3, 1.0–1.7)
5.4
Bladder
0.78 (4.2, 3.6–4.9)*
0.26 (1.4, 0.81–2.3)
0.28 (1.5, 0.96–2.3)
0.29 (1.5, 0.99–2.4)
0.19
Data are mean values of 8–10 animals in each group
* = P

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Table 4
Specific activity of GSTmu in nmol/min/mg of protein (Ratio of the treated/control enzyme specific activities, 95% Confidence Intervals)

Sulforaphane
BNF
Curcumin
DMF
Control
Liver
0.09 (0.39, 0.25–0.62)*
0.20 (0.87, 0.71–1.1)
0.23 (1.0, 0.79–1.3)
0.29 (1.3, 1.0–1.6)
0.23
Kidney
0.06 (3.0, 0.92–9.7)
0.03 (1.5, 0.46–4.9)
0.21 (10, 3.2–34)*
0.02 (1.0, 0.25–4.0)
0.02
Prostate
0.73 (1.9, 1.4–2.4)*
0.76 (1.9, 1.5–2.5)*
0.67 (1.7,1.4–2.1)*
0.34 (0.87, 0.69–1.1)
0.39
Data are mean values of 8–10 animals in each group
* = P

 

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