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Investigated if carcinogen defense (phase 2) enzymes could be induced in the prostate …


Biology Articles » Biochemistry » Enzymology » Modest induction of phase 2 enzyme activity in the F-344 rat prostate » Figures

Figures
- Modest induction of phase 2 enzyme activity in the F-344 rat prostate

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Figure 1 Fold-induction of phase 2 enzymes NQO1, total GST and GST-mu activity in the prostate tissue of male F344 rats treated for 5 days with 50 mg/Kg Sulforaphane (n = 8), 45 mg/Kg Curcumin (n = 10), 41 mg/Kg β-naphthoflavone (n = 10) and 37.5 mg/Kg Dimethylfumarate (n = 10). Fold-induction is the ratio of specific activity of treated against control animals (n = 10) and is plotted on a log scale. Data represent average of assays in triplicate. Data are mean and 95% confidence intervals of animals in each group.

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Figure 2 Fold-induction in NQO1 (A) and total GST (B) enzyme activities in the liver, kidney and bladder tissues of male F344 rats treated for 5 days with 50 mg/Kg Sulforaphane (n = 8), 45 mg/Kg Curcumin (n = 10), 41 mg/Kg β-naphthoflavone (n = 10) and 37.5 mg/Kg Dimethylfumarate (n = 10). Fold-induction is the ratio of specific activity of treated against control animals (n = 10) and is plotted on a log scale. Data represent the average of assays in triplicate. Data are mean 95% confidence intervals of animals in each group.

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