Increasing evidence on the need of the higher forms of life for …

• Abstract
• Introduction
• Model Studies Related to Vanadium Metabolism
• Other Models of Biochemical Interest
• Model Studies Related to Vanadium Detoxification
• Model Studies Related to Haloperoxidases
• Conclusions and Perspectives
• References
• Figures and Table

Model studies related to vanadium biochemistry: recent advances and perspectives

Enrique J. Baran

Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C. Correo 962, 1900-La Plata, Argentina

An open access article from J. Braz. Chem. Soc. vol.14 no.6 São Paulo Nov./Dec. 2003.

ABSTRACT

Increasing evidence on the need of the higher forms of life for vanadium has accumulated during recent years. Model studies have become a very important tool to attain a better understanding of different aspects of the biochemistry of this bioelement. In this account we present the results of our own studies, as well as those of other research groups, on models related to different aspects of its metabolism and detoxification and to vanadium dependent haloperoxidases. Additional information about the interaction of the biologically relevant oxovanadium(IV) cation with important bioligands, such as nucleotides, carbohydrates, phosphates and related systems are also presented.

Keywords: vanadium, model studies, metabolism, detoxification, haloperoxidases, biologically relevant ligands