This review focuses on the role that metal-responsive transcription factors have in …

• Introduction
• Iron
• Copper
• Zinc
• Conclusions
• References
• Figures
• Table

Biology Articles » Cell biology » Metal-Responsive Transcription Factors That Regulate Iron, Zinc, and Copper Homeostasis in Eukaryotic Cells » Table

Table

- Metal-Responsive Transcription Factors That Regulate Iron, Zinc, and Copper Homeostasis in Eukaryotic Cells

TABLE 1. Genes that are regulated by metal-responsive transcription factors^a

Transcription factorb Description Gene name(s) Reference(s) Aft1 Transporters FET4, FET5, FTR1, FTH1, SMF3, MRS4, CCC2, COT1 72, 115, 124, 125, 149, 156 Cu chaperone ATX1 93 Ferroxidase FET3, FET5 124, 154 Metalloreductases FRE1, FRE2, FRE3, FRE4, FRE5, FRE6 98, 154 Cell wall proteins FIT1, FIT2, FIT3 117 Siderophore transport ARN1, ARN2, ARN3, ARN4 162 Fe-S biosynthesis ISU1, ISU2 47 Otherd TIS11, HMX1, AKR1, PCL5, YOR387c, YHL035c, YMR034c, ICY2, PRY1, YDL124w 44, 118, 125, 135 Aft2 Transporters SMF3, MRS4, FTR1, COT1 115, 125 Cu chaperone ATX1 14 Ferroxidase FET3, FET5 14, 124 Metalloreductase FRE1 125 Cell wall protein FIT1, FIT3, FIT2 124, 125 Fe-S biosynthesis ISU1 125 Otherd BNA2, ECM4, LAP4, TIS11, YOL083w, YGR146c, YHL035c 125 Fep1 Transporter fip1+ 107 Ferroxidase fio+ 107 Siderophore transport str1+, str2+, str3+ 108 SREA Siderophore biosynthesis sidA, sidB, sidC, amcA, atrH, estA 103 Siderophore transport mirA, mirB, mirC 103 Otherd cycA, acoA, lysF 102 Urbs1 Siderophore biosynthesis sid1, sid2 2, 161 Ace1 Cu metallothioneins CUP1, CRS5 29, 139, 150 Cellular stress response SOD1 55 Amt1 Cu metallothioneins MT-I, MT-IIa, MT-IIb 141, 172 Gene regulation AMT1 174 Crf1 Cu metallothioneins MTPI, MTPI1 46 Mac1 Cu transporters CTR1, CTR3 85, 155 Metalloreductases FRE1, FRE7 49, 98 Otherd YFR055w, YJL217w, YLR213c 57 Cuf1 Cu transporters ctr4+, ctr5+, ctr6+ 7, 9, 84 Fe transport fip+c 84 Metalloreductase frp1+c 84 Multicopper oxidase fio1+c 84 GRISEA Cu transport PaCTR3 16 Cellular stress response PaSOD2 18 Crr1 Heme biosynthesis CPX1 68 Photosystem I maintanence CRD1, CTH1c 100, 101 Electron transfer CYC6 67, 99 Zap1 Zn transporters ZRT1, ZRT2, ZRT3, ZRC1, FET4, ZRG17 94, 95, 96, 149, 159, 166, 167 Gene regulation ZAP1, NRG2 94, 168 Phosphate/lipid metabolism YOL002c 94 Metabolic enzymes DPP1, ADH4, MNT2, ADE17, TKL2, URA10 94 Vacuolar proteases PRC1, PEP4 94 Otherd MCD4, ZPS1, RAD27, ZIP1, GRE2, BAG7, FLO1, YNL254c, YLL020c, YGL258w, YOR387c, YJR061w, YMR086w, YOL131w, GPG1, COS1, COS2, COS3, COS4, COS6, COS8, YJL132w, ICY2, PST1, YBL048w, YBL049w, YNL234w, YDR492w, YKL174c, PHM7 94, 159 Mammalian MTF-1 Zn transporters ZNT-1, ZTL1 27, 87 Metallothioneins MT-I, MT-II 66 Cellular stress response AFP, LCN1, PIGF, -GCS 56, 59, 92 Other AHSG, CBG, PMP22, XIST, ACVR2b 92 Drosophila MTF-1 Metallothioneins MTNA, MTNB, MTNC, MTND 38, 163

^a The genes that are listed are (i) metal regulated and (ii) have a consensus sequence or sequence that resembles the consensus binding site for the relevant transcription factor within the promoter region and/or encode for a protein that is involved in metal metabolism. Genes that have been analyzed in such a way to demonstrate a more direct interaction with the factor in question are shown in bold. Examples of experimental evidence that is consistent with a direct interaction include analysis of expression in the presence and absence of the wild-type or constitutive alleles of the relevant factor and/or the use of reporter constructs containing the metal-responsive element(s) of the target gene in question.

^b No target gene has been identified for the SRE and SreP transcription factors.

^c Genes that are repressed, rather than activated, by the named transcription factor.

^d Genes which do not fall into any of the listed categories.