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Aspergillus nidulans is a model organism for aspergilli, which are an important …


Biology Articles » Mycology » Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans » Figures

Figures
- Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans

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Figure 1 Biomass and substrate profiles for the different batch cultivations carried out with A. nidulans. (a) Cultivation with glucose as carbon source. (b) Cultivation with glycerol as carbon source. (c) Cultivation with ethanol as carbon source. For all cultivations, the time of sampling, the biomass concentration at the time of sampling, and the maximum specific growth rate for the culture are given.

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Figure 2 Representation of the eight clusters of genes identified. The numbers of genes in each cluster are as follows: 280 in cluster 1, 146 in cluster 2, 184 in cluster 3, 206 in cluster 4, 92 in cluster 5, 125 in cluster 6, 254 in cluster 7, and 212 in cluster 8. The x-axis represents the different carbon sources investigated: 1, glucose; 2, ethanol; and 3, glycerol. The y-axis represents normalized intensities, according to Grotkjær and coworkers [19]. Cluster 9 contains discarded genes, with low assignment to any of the other clusters.

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Figure 3 Small subnetwork identified for the shift from glucose to ethanol as carbon source. Genes marked red are upregulated and genes marked green are downregulated upon the shift. The metabolic map is simplified (many transport reactions are not included and the two steps of the glycoxylate pathway [encoded by the genes acuD and acuE] are placed in the mitochondria even though they are really located in the glyoxysomes). Conversions that involve several steps are indicated by dashed arrows. The metabolites are as follows: ACCOA, acetyl-CoA; ACE, acetate; ACHO, acetaldehyde; CIT, citrate; F16BP, fructose 1,6-bisphosphate; F6P, fructose 6-phosphate; G6P, glucose 6-phosphate; GLY, glyoxylate; ICIT, isocitrate; MAL, malate; OAA, oxaloacetate; PEP, phosphoenolpyruvate; PYR, pyruvate; SUC, succinate.

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