Login

Join for Free!
116860 members
table of contents table of contents

Biology Articles » Cell biology » Membrane fusion in cells: molecular machinery and mechanisms » Figure

Figure
- Membrane fusion in cells: molecular machinery and mechanisms

..................................................

Fig. 1 Schematic diagram depicting synaptic vesicle fusion at the base of porosome, leading to neurotransmitter release at the nerve terminal. (A) Note, in presence of NSF, t-SNARE and v-SNARE fail to form a complex. (B) In the absence of active NSF, t-SNAREs and v-SNARE interact in a circular array to form a channel, bringing the opposing bilayers within a distance of 2.8–3 Å. (C) If the t-/v-SNARE channel is formed in the presence of calcium, the hydrated calcium ion looses its water shell by bridging with the opposing phospholipid head groups, resulting in lipid mixing and the establishment of a conducting t-/v-SNARE channel. (D) Secretory vesicles, with a buildup of intra vesicular pressure, can then pump out the vesicular contents through the SNARE channel (actual atomic force micrograph of neuronal t-/v-SNARE ring channel is shown) and out the porosome opening.

..................................................

Source: J. Cell. Mol. Med. Vol 10, No 2, 2006 pp. 423-427


rating: 6.40 from 15 votes | updated on: 10 Dec 2006 | views: 14656 |

Rate article:







excellent!bad…