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In this review we highlight the candidate molecules involved in the sperm–…


Biology Articles » Reproductive Biology » The mechanism of sperm–oocyte fusion in mammals » Table

Table
- The mechanism of sperm–oocyte fusion in mammals

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Table 1 Phenotype of oocyte and sperm from knockout mice in sperm–oocyte interaction.

  Molecule Binding/fusion Reference

Oocyte CD9 normal/reduced Miller et al. 2000; Miyado et al. 2000; Kaji et al. 2000, 2002
  GPI-anchor protein ~60%/reduced Alfieri et al. 2003
  (PIG-A)    
  integrin    
      {alpha}3 normal/normal He et al. 2003
      {alpha}6 normal/normal Miller et al. 2000
      ß1 normal/normal He et al. 2003
      ß3 normal* Hodivala-Dilke et al. 1999
      ß5 normal* Huang et al. 2000
Sperm fertilin ß reduced/~50% Cho et al. 1998
  cyritestin reduced/normal Nishimura et al. 2001


reduced, more than 80% reduction; %, of control; *, normal number of pups in natural mating.


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Source: Reproduction (2004) 127 423-429


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