In this review we highlight the candidate molecules involved in the sperm–…

• Abstract
• Introduction
• Candidate molecules involved in the sperm–oocyte interaction
• Conclusions and perspectives
• References
• Figures
• Table

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Table 1 Phenotype of oocyte and sperm from knockout mice in sperm–oocyte interaction.

Molecule Binding/fusion Reference Oocyte CD9 normal/reduced Miller et al. 2000; Miyado et al. 2000; Kaji et al. 2000, 2002   GPI-anchor protein ~60%/reduced Alfieri et al. 2003   (PIG-A)       integrin           3 normal/normal He et al. 2003       6 normal/normal Miller et al. 2000       ß1 normal/normal He et al. 2003       ß3 normal* Hodivala-Dilke et al. 1999       ß5 normal* Huang et al. 2000 Sperm fertilin ß reduced/~50% Cho et al. 1998   cyritestin reduced/normal Nishimura et al. 2001 reduced, more than 80% reduction; %, of control; *, normal number of pups in natural mating.

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Source: Reproduction (2004) 127 423-429