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Resistance to anti-tuberculosis drugs is a serious public health problem.

Biology Articles » Medicine » Pharmacology » Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda » Tables

Tables
- Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda

Table 1
Susceptibility of isolates tested by BACTEC 460 and Phage assay.
Assay
 Drug concentration μg/ml
 Susceptible Isolates
 Resistant isolates
BACTEC 460
 2
 114
 35*
Phage
 2
 91
 58
Phage
 4
 110
 39
Phage
 10
 110
 39
* All 35 isolates found resistant by BACTEC 460 were also found to be resistant by the phage assay (at each concentration).
Table 2
Mutations in the rpoB core region for 39 M. tuberculosis isolates found resistant to rifampicin by the phage assay.
Mutation
 Number of isolates.
Ser531Leu
 18
Asp516Val
 9
Asp516Tyr
 2
Leu511Pro
 2
His526Tyr
 2
Gln513Lys
 1
Leu533Pro
 1
Asp516Tyr
 1
Ser531Leu & His526Tyr
 1
Asp516Val & His526Tyr
 1
No mutation
 1
Total
 39

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