The author(s) declare that they have no competing interests.
GJ, ELR, AD, JM and SBO performed the experimental work. GJ, ELR, AD, FN, GP and SB conceived the experimental strategies and designed individual experiments. SBO, GF and SB analyzed the data and GJ and SB wrote the manuscript. All authors read and approved the final manuscript.
This work was supported in part by INSERM, CNRS, Université Paris-Descartes and the French National Agency for AIDS Research (ANRS), Sidaction and Fondation de France (SB, GP and FN). GJ is a recipient fellowship of the French Ministery of Research.
We thank C. Dargemont and Alexandre Benmerah for active supports, discussion, and critical reading of the manuscript.