The authors explored the contribution of Vpr accumulation at the NE to …

• Abstract
• Background
• Results
• Discussion
• Conclusion
• Methods
• Miscellaneous
• References
• Figures

The present study shows that the targeting of Vpr to the nuclear pore complex may constitute an early step toward Vpr-induced G2-arrest and subsequent apoptosis. However, this localization at the NE is not absolutely required, but could improve HIV-1 replication in macrophages.