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Biology Articles » Biochemistry » An insight into the biochemistry of inborn errors of metabolism for a clinical neurologist » Tandem mass spectrometry

Tandem mass spectrometry
- An insight into the biochemistry of inborn errors of metabolism for a clinical neurologist

Tandem mass spectrometry (Tandem MS or MS-MS) is a major technological advance in the screening for inherited metabolic diseases.[33] It has the potential for simultaneous and robust multiple disease screening using a single analytical technique. It permits the expansion of screening of many disorders of organic and amino acid metabolism and fatty acid oxidation disorders. Only few spots of blood on a filter paper are required to prepare an adequate specimen. The utility and application of MS-MS has been demonstrated in many countries worldwide.[34],[35] This facility is available at NIMHANS, Bangalore and Lal PathLabs, New Delhi.

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