Insulin sensitivity and insulin secretion are mutually related such that insulin resistance …

• Abstract
• Insulin sensitivity vs insulin secretion
• The hyperbolic relationship in experimental animals
• Measurement of insulin sensitivity and insulin secretion
• Clinical consequences
• Basic mechanisms
• Methodological suggestions
• Concluding remarks
• References
• Figures
• Table

Accurate estimation of insulin secretion and insulin sensitivity requires determination of both variables because they need to be judged in relationship to each other. The nature of the relationship in different populations and different clinical groups needs now to be established. We also need a deeper understanding of the basic mechanism relating these two processes to each other and why the compensatory insulin secretion in insulin resistance fails in type 2 diabetes.

Acknowledgements

The studies by the authors have been supported by the Swedish Research Council (grant no 6834), Albert Pa°hlsson Foundation, Swedish Diabetes Association, Donation Funds of the Lund University Hospital, and the Faculty of Medicine, Lund University, and from ISIB-CNR (formerly LADSEB), Padua, Italy.