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Figures
- The impact of tissue engineering on dentistry

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Figure 1. Chemical structures and typical physical forms for polymers used in tissue engineering. A. Chemical structures of biodegradable polyesters commonly used to fabricate tissue-engineering scaffolds. B. Photomicrograph of a polyglycolic acid fiber-based scaffold. C. Photomicrograph of a poly(lactic-co-glycolic acid) porous sponge. Size bars are shown on the photomicrographs. (Photomicrographs from Kim and colleagues.14)

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Figure 2. A tissue-engineering approach that uses cultured cells and biodegradable polymer scaffolds. Tissue-specific cells are isolated from a biopsy specimen, expanded in culture and combined with a porous biodegradable polymer scaffold. The cells adhere to the scaffold, proliferate and, over time, form a new tissue that can be returned to the tissue donor or to another patient.

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Figure 3. Schematic representation of a possible first-generation artificial salivary gland composed of a fluid-secreting blind-end tube. (Adapted with permission of the New York Academy of Sciences from Baum and colleagues.52)

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Figure 4. Effect of AdhAQP1 infection on fluid secretion from irradiated rat submandibular glands. All animals were either sham-irradiated or irradiated with 21 gray to the salivary glands. After four months, the glands were infected with either a control virus (Addl312) or the experimental virus (AdhAQP1) encoding the water channel aquaporin-1. Three days later, animals were stimulated with pilocarpine to secrete saliva. (Data are from Delporte and colleagues.54) (Figure reprinted with permission of the International Association for Dental Research from Baum and O’Connell.53)

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