This study was conducted to evaluate the immunohistochemical (IHC) expression of interleukin 8 (…

• Abstract
• Background
• Materials and methods
• Results
• Discussion
• Conclusion
• Abbreviations
• References
• Figure
• Tables

Biology Articles » Medicine » Dermatology » Immunohistochemical expression of interleukin 8 in skin biopsies from patients with inflammatory acne vulgaris » Results

Results

- Immunohistochemical expression of interleukin 8 in skin biopsies from patients with inflammatory acne vulgaris

Sixty two percent of the patients were adolescents. Most of patients were females (82.7%) and 79.3% had positive family history of IAV. Almost half (51.7%) of the patients had a disease duration less than 1 year. The exposure to comedogenic agents was positive in 41.4% and history of medications known to cause acne was seen in 34.5%. The demographic characteristics of the patients are summarized in table 1.

IHC expression of IL8 was homogenous and confined to the cytoplasm of the cells. It was identified in all IAV patients with variable expressions in the epidermis and dermis ranging from mild to strong. In the epidermis, all keratinocytes were stained. In the dermis the expression was identified in the pilosebaceous units, inflammatory cells and endothelial cells. In the control group only two cases showed mild epidermal expression, while no staining was observed in the remaining cases (figure 1).

Strong association has been found between the extent of epidermal hyperplasia and hyperkeratosis and the epidermal IHC expression of IL-8 (p 2 illustrates these associations.