A study on the immunomodulatory role of curcumin in a mouse model …

• Abstract
• Materials and Methods
• Results
• Discussion
• Conclusion
• Abbreviations
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Biology Articles » Immunobiology » Immune response modulation by curcumin in a latex allergy model » Conclusion

Conclusion

- Immune response modulation by curcumin in a latex allergy model

The results presented in this report clearly suggest that curcumin, the active ingredient of turmeric, is capable of reducing or suppressing the Th2 response induced in mice by exposing them to latex allergens. Although the exact mechanism is not clearly understood, it is possible that a number of different mechanisms are concurrently at work. This may include suppression of Th2 responses as evidenced by reduced IL-4 and IL-13 production and depletion of eosinophils in the lungs, and attenuation of lung inflammation through expression of molecules such as TSLP, MMP-9, and OAT. The results indicate that curcumin has potential therapeutic value in allergy. However, further studies are needed to understand the exact mechanism involved in curcumin induced suppression of allergic responses.