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Figure 1 Flowchart of the process used to generate the prioritized list of tractable therapeutic targets.
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Figure 2 Overlap of the top 400 highest-scoring genes (~10% of the genome) from each of the three types of experimental models of dormancy. Murine refers to M. tuberculosis cells isolated from mouse macrophages, subcutaneous hollow fiber, and lung.
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Figure 3 Ratio of the number of genes in the highest-scoring fraction (top 10%) to the number in the entire genome, for each classification described in Cole, et al. [17]. Ratios greater than 1 indicate that the genes are over-represented in the highest-scoring fraction relative to their representation in the whole genome.
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Figure 4 Histogram of the distribution of upregulated and downregulated gene scores for the entire genome overlaid with the distribution from the devR regulon (A) and the relA regulon (B).
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Figure 5 The two biosynthetic pathways for isopentenyl-pyrophosphate biosynthesis. The gene products (enzymes) from the M. tuberculosis genome presumed to catalyze each transformation are specified by the Rv numbers. Enzymes for which there is not a relevant orthologue in the M. tuberculosis genome are labeled as missing. [119] [76].
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