These findings contribute to define the growing group of human polyserine proteases …

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Biology Articles » Biochemistry » Protein Biochemistry » Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain » Conclusion

Conclusion

- Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain

The identification of the third human polyserase allows establishing the polyserases as a group of enzymes containing different tandem serine protease domains. These findings raise new questions about the functions of these intriguing polyenzymes and their possible involvement in human diseases. In particular, the search for the in vivo substrates of polyserase-3 and the generation of mice deficient in this gene would contribute to ascertain the relevance of this enzyme in both normal and pathological conditions. Finally, the resolution of the three- dimensional structure of polyserase-3 and that of the remaining human polyserases, could help to understand the functional relevance of the presence of several catalytic domains within the same polypeptide chain.