Supporting Information
- Human MicroRNA Targets

Figure S1. Overrepresentation of the GO and Interpro Domains

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Table S1. Human miRNAs in Introns

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Table S2. Predicted Mammalian miRNA Targets by Gene

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Table S3. Predicted Mammalian miRNA Targets by miRNA

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Table S4. Predicted Fish Targets by Gene

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Table S5. Predicted Fish Targets by miRNA

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Table S6. High-Scoring miRNA Matches in Human cDNAs

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Table S7. High-Scoring miRNA Matches in Human Coding Regions

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Table S8. Estimate of False Positives

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Table S9. Predicted Targets That Are Associated with FMRP

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Table S10. Function of Targets by Interpro and GO Mapping

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Table S11. Target Genes That Contain Predicted CPE Motifs

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Table S12. Conserved Vertebrate Target Genes

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Table S13. Overlap of the Predicted Targets with Validated Gene Targets from Lewis et al. (2003) and Kiriakidou et al. (2004).

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Acknowledgments

We thank Rebecca Ward and Ulrike Gaul for intellectual input and support, Nathan Marks for help with FMRP datasets, Russell Oliver Kosik for help with compiling expression data, and Joanne Edington for computer systems support.

Conflicts of interest. The authors have declared that no conflicts of interest exist.

Author contributions. CS and DMS conceived and directed the project. BJ, AJE, CS, and DSM worked on the algorithm. BJ, AJE, and DSM prepared the input data. BJ and AJE wrote the computer programs. BJ, AA, TT, CS, and DSM analyzed the ouput data. TT contributed microRNA expression data. BJ, CS, and DSM wrote the paper with assistance from AJE.