In this review, the authors described several recent HIV-1 studies in which …

• Abstract
• Introduction to the HIV-1 drug-dependence phenomenon
• HIV-1 entry and the T20-dependence phenotype
• How general is the T20-dependence phenotype: a common HR1-HR2 theme
• T20-like drugs: a common HR1-HR2 theme
• Other drug-dependencies in the Env protein
• Drug-enhancement of the HIV-1 protease
• Drug-dependence of the HIV-1 Gag protein
• Clinical implications of drug-dependent viruses
• Acknowledgements
• References
• Table 01
• Figures

We would like to thank Rogier Sanders for critically reading the manuscript. This review was supported in part by grant number 2005021 from the AIDS fund (Amsterdam).