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The 3,4-dihydroxy phenyl L-alanine (L-dopa) is a drug of choice for Parkinson's …

Biology Articles » Biotechnology » High performance microbiological transformation of L-tyrosine to L-dopa by Yarrowia lipolytica NRRL-143 » Table

Table
- High performance microbiological transformation of L-tyrosine to L-dopa by Yarrowia lipolytica NRRL-143

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Comparison of parameters for L-dopa production by Y. lipolytica NRRL-143
Production parameters*
 Control
 Test**
Proteins (mg/ml)
 0.34
 4.06
Yp/s
 0.590
 1.071
Qs
 0.073
 0.329
qs
 0.002
 0.011
Optimal pH$
 3.5
 2.5–4.0
Max. L-dopa production (mg/ml)
 0.28
 3.48
Level of significance

*$

 -
 HS

*Kinetic parameters: Yp/s = mg L-dopa produced/mg substrate consumed, Qs = mg substrate consumed/ml/h, qs = mg substrate consumed/mg cells/h.

**2.0 mg/ml diatomite added 15 min after the start of reaction.

$Acetate buffer

*$ is for significance level (≈0.05) on the basis of probability. HS denotes that the values are highly significant.

Ali et al. BMC Biotechnology 2007 7:50   doi:10.1186/1472-6750-7-50

 

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