1 Yokoyama HO, Wilson ME, Tsuboi KK, Stowell RE. Regeneration of mouse liver after partial hepatectomy. Cancer Res 1953; 13: 80-85
2 Kanno N, LeSage G, Glaser S, Alvaro D, Alpini G. Functional heterogeneity of the intrahepatic biliary epithelium. Hepatology 2000; 31: 555-561
3 Alpini G, Prall RT, LaRusso NF. The pathobiology of biliary epithelia. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Jakoby W, Schachter D, and Shafritz DA, eds.The Liver; Biology & Pathobiology, 4th ed.Philadelphia, PA: Lippincott Williams & Wilkins 2001: 421-435
4 Nathanson MH, Boyer JL. Mechanisms and regulation of bile secretion. Hepatology 1991; 14: 551-566
5 Kanno N, LeSage G, Glaser S, Alpini G. Regulation of cholangiocyte bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 2001; 281: G612-625
6 Alpini G, Lenzi R, Sarkozi L, Tavoloni N. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules. J Clin Invest 1988; 81: 569-578
7 Glaser SS, Rodgers RE, Phinizy JL, Robertson WE, Lasater J, Caligiuri A, Tretjak Z, LeSage GD, Alpini G. Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes. Am J Physiol 1997; 273: G1061-1070
8 Ludwig J. New concepts in biliary cirrhosis. Semin Liver Dis 1987; 7: 293-301
9 Ludwig J, Ritman EL, LaRusso NF, Sheedy PF, Zumpe G. Anatomy of the human biliary system studied by quantitative computer-aided three-dimensional imaging techniques. Hepatology 1998; 27: 893-899
10 Schaffner F, Popper H. Electron microscopic studies of normal and proliferated bile ductules. Am J Pathol 1961; 38: 393-410
11 Carruthers JS, Steiner JW. Studies on the fine structure of proliferated bile ductules. I. Changes of cytoarchitecture of biliary epithelial cells. Can Med Assoc J 1961; 85: 1223-1236
12 Alpini G, Roberts S, Kuntz SM, Ueno Y, Gubba S, Podila PV, LeSage G, LaRusso NF. Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology 1996; 110: 1636-1643
13 Alpini G, Glaser S, Robertson W, Rodgers RE, Phinizy JL, Lasater J, LeSage GD. Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion. Am J Physiol Gastrointest Liver Physiol 1997; 272: G1064-1074
14 Benedetti A, Bassotti C, Rapino K, Marucci L, Jezequel AM. A morphometric study of the epithelium lining the rat intrahepatic biliary tree. J Hepatol 1996; 24: 335-342
15 Masyuk TV, Ritman EL, LaRusso NF. Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction. Am J Pathol 2001; 158: 2079-2088
16 Phillips MJ, Poucell S, Patterson J, Valencia P. The normal liver. In: Phillips MJ, Powell S, Patterson S, Valencia P, eds. The liver: an atlas and text of ultrastructural pathology. New York, NY: Raven Press, 1987: 1-35
17 LaRusso NF, Ishii M, Vroman BT. The ins and outs of membrane movement in biliary epithelia. Trans Am Clin Climatol Ass 1990; 102: 245-258; discussion 258-259
18 Ishii M, Vroman B, LaRusso NF. Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver. Gastroenterology 1989; 97: 1236-1247
19 Vroman B, LaRusso NF. Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. Lab Invest 1996; 74: 303-313
20 Masyuk TV, Huang BQ, Ward CJ, Masyuk AI, Yuan D, Splinter PL, Punyashthiti R, Ritman EL, Torres VE, Harris PC, LaRusso NF. Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat. Gastroenterology 2003; 125: 1303-1310
21 Ishii M, Vroman B, LaRusso NF. Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells. Gastroenterology 1990; 98: 1284-1291
22 Elsing C, Hubner C, Fitscher BA, Kassner A, Stremmel W. Muscarinic acetylcholine receptor stimulation of biliary epithelial cells and its effect on bile secretion in the isolated perfused liver [corrected]. Hepatology 1997; 25: 804-813
23 Alvaro D, Alpini G, Jezequel AM, Bassotti C, Francia C, Fraioli F, Romeo R, Marucci L, Le Sage G, Glaser SS, Benedetti A. Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions. J Clin Invest 1997; 100: 1349-1362
24 Gigliozzi A, Alpini G, Baroni GS, Marucci L, Metalli VD, Glaser SS, Francis H, Mancino MG, Ueno Y, Barbaro B, Benedetti A, Attili AF, Alvaro D. Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis. Gastroenterology 2004; 127: 1198-1209
25 Glaser S, Alvaro D, Roskams T, Phinizy JL, Stoica G, Francis H, Ueno Y, Barbaro B, Marzioni M, Mauldin J, Rashid S, Mancino MG, LeSage G, Alpini G. Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. Am J Physiol Gastrointest Liver Physiol 2003; 284: G683-694
26 LeSage G, Alvaro D, Benedetti A, Glaser S, Marucci L, Baiocchi L, Eisel W, Caligiuri A, Phinizy JL, Rodgers R, Francis H, Alpini G. Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats. Gastroenterology 1999; 117: 191-199
27 Barbaro B, Glaser S, Francis H, Taffetani S, Marzioni M, LeSage G, Alpini GG. Nerve regulation of cholangiocyte functions. In: Alpini G, Alvaro D, LeSage G, Marzioni M, and LaRusso NF eds. Pathophysiology of the Bile Duct System. Georgetown, Texas, USA: Landes Biosciences,2004: 199-209
28 Reilly FD, McCuskey PA, McCuskey RS. Intrahepatic distribution of nerves in the rat. Anat Rec 1978; 191: 55-67
29 Tsuneki K, Ichihara K. Electron microscope study of vertebrate liver innervation. Arch Histol Jpn 1981; 44: 1-13
30 Gulbenkian S, Wharton J, Hacker GW, Varndell IM, Bloom SR, Polak JM. Co-localization of neuropeptide tyrosine (NPY) and its C-terminal flanking peptide (C-PON). Peptides 1985; 6: 1237-1243
31 Lundberg JM, Terenius L, Hokfelt T, Martling CR, Tatemoto K, Mutt V, Polak J, Bloom S, Goldstein M. Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 1982; 116: 477-480
32 Costa M, Furness JB. Somatostatin is present in a subpopulation of noradrenergic nerve fibres supplying the intestine. Neuroscience 1984; 13: 911-919
33 Gibbins IL, Furness JB, Costa M, MacIntyre I, Hillyard CJ, Girgis S. Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs. Neurosci Lett 1985; 57: 125-130
34 Jule Y, Clerc N, Niel JP, Condamin M. [Met]- and [Leu]enke-phalin-like immunoreactive cell bodies and nerve fibres in the coeliac ganglion of the cat. Neuroscience 1986; 18: 487-498
35 Schultzberg M, Dalsgaard CJ. Enteric origin of bombesin immunoreactive fibres in the rat coeliac-superior mesenteric ganglion. Brain Res 1983; 269: 190-195
36 Burt AD, Tiniakos D, MacSween RN, Griffiths MR, Wisse E, Polak JM. Localization of adrenergic and neuropeptide tyrosine-containing nerves in the mammalian liver. Hepatology 1989; 9: 839-845
37 el-Salhy M, Stenling R, Grimelius L. Peptidergic innervation and endocrine cells in the human liver. Scand J Gastroenterol 1993; 28: 809-815
38 Fava G, Glaser S, Francis H, Phinizy JL, Venter J, Reichenbach R, Taffetani S, Marzioni M, Marucci L, Benedetti A, Alpini G. Neuropeptide Y (NPY) inhibits cholangiocarcinoma growth by interaction with a G-protein coupled receptor by Ca2+-dependent modulation of Src/ERK1/2 phosphorylation. Gastroenterology 2004; 126: AT926
39 Inoue N, Sakai H, Magari S, Sakanaka M. Distribution and possible origins of substance P-containing nerve fibers in the rat liver. Ann Anat 1992; 174: 557-560
40 Goehler LE, Sternini C, Brecha NC. Calcitonin gene-related peptide immunoreactivity in the biliary pathway and liver of the guinea-pig: distribution and colocalization with substance P. Cell Tissue Res 1988; 253: 145-150
41 Akiyoshi H, Gonda T, Terada T. A comparative histochemical and immunohistochemical study of aminergic, cholinergic and peptidergic innervation in rat, hamster, guinea pig, dog and human livers. Liver 1998; 18: 352-359
42 Ohtani O, Kikuta A, Ohtsuka A, Taguchi T, Murakami T. Microvasculature as studied by the microvascular corrosion casting/scanning electron microscope method. I. Endocrine and digestive system. Arch Histol Jpn 1983; 46: 1-42
43 Terada T, Ishida F, Nakanuma Y. Vascular plexus around intrahepatic bile ducts in normal livers and portal hypertension. J Hepatol 1989; 8: 139-149
44 Gaudio E, Onori P, Pannarale L, Alvaro D. Hepatic microcirculation and peribiliary plexus in experimental biliary cirrhosis: a morphological study. Gastroenterology 1996; 111: 1118-1124
45 Yamamoto K, Phillips MJ. A hitherto unrecognized bile ductular plexus in normal rat liver. Hepatology 1984; 4: 381-385
46 Masyuk TV, Ritman EL, LaRusso NF. Hepatic artery and portal vein remodeling in rat liver: vascular response to selective cholangiocyte proliferation. Am J Pathol 2003; 162: 1175-1182
47 LeSage G, Glaser S, Ueno Y, Alvaro D, Baiocchi L, Kanno N, Phinizy JL, Francis H, Alpini G. Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis. Am J Physiol Gastrointest Liver Physiol 2001; 281: G182-190
48 Alpini G, Glaser SS, Ueno Y, Pham L, Podila PV, Caligiuri A, LeSage G, LaRusso NF. Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. Am J Physiol Gastrointest Liver Physiol 1998; 274: G767-775
49 Alpini G, Ueno Y, Glaser S, Marzioni M, Phinizy JL, Francis H, LeSage G. Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes. Hepatology 2001; 34: 868-876
50 LeSage GD, Glaser S, Marucci L, Benedetti A, Phinizy JL, Rodgers R, Caligiuri A, Papa E, Tretjak Z, Jezequel AM, Holcomb LA, Alpini G. Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. Am J Physiol 1999; 276: G1289-1301
51 LeSage GD, Benedetti A, Glaser S, Marucci L, Tretjak Z, Caligiuri A, Rodgers R, Phinizy JL, Baiocchi L, Francis H, Lasater J, Ugili L, Alpini G. Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver. Hepatology 1999; 29: 307-319
52 LeSage G, Glaser S, Robertson W, Phinizy JL, Rodgers R, Alpini G. Partial hepatectomy induces proliferative and secretory events in small cholangiocytes. Gastroenterology 1996; 110: A1250
53 Alpini G, Ulrich CD 2nd, Phillips JO, Pham LD, Miller LJ, LaRusso NF. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. Am J Physiol 1994; 266: G922-928
54 Alpini G, Ulrich C, Roberts S, Phillips JO, Ueno Y, Podila PV, Colegio O, LeSage GD, Miller LJ, LaRusso NF. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol 1997; 272: G289-297
55 Tietz PS, Alpini G, Pham LD, Larusso NF. Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes. Am J Physiol 1995; 269: G110-118
56 Cho WK, Mennone A, Rydberg SA, Boyer JL. Bombesin stimulates bicarbonate secretion from rat cholangiocytes: implications for neural regulation of bile secretion. Gastroenterology 1997; 113: 311-321
57 Cho WK. Role of the neuropeptide, bombesin, in bile secretion. Yale J Biol Med 1997; 70: 409-416
58 Cho WK, Boyer JL. Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes. Gastroenterology 1999; 117: 420-428
59 Caligiuri A, Glaser S, Rodgers RE, Phinizy JL, Robertson W, Papa E, Pinzani M, Alpini G. Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes. Am J Physiol 1998; 275: G835-846
60 Alvaro D, Benedetti A, Marucci L, Delle Monache M, Monterubbianesi R, Di Cosimo E, Perego L, Macarri G, Glaser S, Le Sage G, Alpini G. The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat. Hepatology 2000; 32: 174-184
61 Alpini G, Glaser SS, Ueno Y, Rodgers R, Phinizy JL, Francis H, Baiocchi L, Holcomb LA, Caligiuri A, LeSage GD. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Gastroenterology 1999; 116: 179-186
62 Alpini G, Baiocchi L, Glaser S, Ueno Y, Marzioni M, Francis H, Phinizy JL, Angelico M, LeSage G. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology 2002; 35: 1041-1052
63 Baiocchi L, Alpini G, Glaser S, Angelico M, Alvaro D, Francis H, Marzioni M, Phinizy JL, Barbaro B, LeSage G. Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. J Hepatol 2003; 38: 136-147
64 Baiocchi L, LeSage G, Glaser S, Alpini G. Regulation of cholangiocyte bile secretion. J Hepatol 1999; 31: 179-191
65 LeSage GD, Alvaro D, Glaser S, Francis H, Marucci L, Roskams T, Phinizy JL, Marzioni M, Benedetti A, Taffetani S, Barbaro B, Fava G, Ueno Y, Alpini G. Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP. Hepatology 2004; 40: 1116-1127
66 Francis H, Glaser S, Alvaro D, Taffetani S, Marucci L, Benedetti A, Ueno Y, Marzioni M, LeSage G, Venter J, Baumann B, Phinizy JL, Alpini G. The α-2 adrenergic receptor agonist, UK14,304, inhibits secretin-stimulated ductal secretion of bile duct ligated (BDL) rats by activation of the G-protein Gαi. Hepatology 2003; 38: A1088
67 Marzioni M, Glaser S, Francis H, Marucci L, Benedetti A, Alvaro D, Taffetani S, Ueno Y, Roskams T, Phinizy JL, Venter J, Fava G, LeSage GD, Alpini G. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology 2005; 128: 121-137
68 LeSage G, Glaser S, Alpini G. Regulation of cholangiocyte proliferation. Liver 2001; 21: 73-80
69 Alvaro D, Alpini G, Onori P, Franchitto A, Glaser S, Le Sage G, Gigliozzi A, Vetuschi A, Morini S, Attili AF, Gaudio E. Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes. Gastroenterology 2002; 123: 336-344
70 Francis H, Glaser S, Ueno Y, LeSage G, Marucci L, Benedetti A, Taffetani S, Marzioni M, Alvaro D, Venter J, Reichenbach R, Fava G, Phinizy JL, Alpini G. cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway. J Hepatol 2004; 41: 528-537
71 Glaser S, Francis H, Marzioni M, Taffetani S, Phinizy JL, LeSage G, Alpini G. Functional heterogeneity of the intrahepatic biliary epithelium. In: Alpini G, Alvaro D, LeSage G, Marzioni M, and LaRusso NF eds. Pathophysiology of the Bile Duct System. Georgetown, Texas, USA: Landes Biosciences 2004: 245-254
72 Glaser S, Benedetti A, Marucci L, Alvaro D, Baiocchi L, Kanno N, Caligiuri A, Phinizy JL, Chowdury U, Papa E, LeSage G, Alpini G. Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms. Hepatology 2000; 32: 17-25
73 Marzioni M, Glaser SS, Francis H, Phinizy JL, LeSage G, Alpini G. Functional heterogeneity of cholangiocytes. Semin Liver Dis 2002; 22: 227-240
74 Alvaro D, Mennone A, Boyer JL. Role of kinases and phosphatases in the regulation of fluid secretion and Cl-/HCO3- exchange in cholangiocytes. Am J Physiol 1997; 273: G303-313
75 Ueno Y, Alpini G, Yahagi K, Kanno N, Moritoki Y, Fukushima K, Glaser S, LeSage G, Shimosegawa T. Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice. Liver Int 2003; 23: 449-459
76 Alpini G, Phillips JO, Vroman B, LaRusso NF. Recent advances in the isolation of liver cells. Hepatology 1994; 20: 494-514
77 LeSage GD, Marucci L, Alvaro D, Glaser SS, Benedetti A, Marzioni M, Patel T, Francis H, Phinizy JL, Alpini G. Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. Hepatology 2002; 36: 641-651
78 Okada Y, Jinno K, Moriwaki S, Shimoe T, Tsuji T, Murakami M, Thurin J, Koprowski H. Blood group antigens in the intrahepatic biliary tree. I. Distribution in the normal liver. J Hepatol 1988; 6: 63-70
79 Terada T, Kono N, Nakanuma Y. Immunohistochemical and immunoelectron microscopic analyses of alpha-amylase isozymes in human intrahepatic biliary epithelium and hepatocytes. J Histochem Cytochem 1992; 40: 1627-1635
80 Terada T, Morita T, Hoso M, Nakanuma Y. Pancreatic enzymes in the epithelium of intrahepatic large bile ducts and in hepatic bile in patients with extrahepatic bile duct obstruction. J Clin Pathol 1994; 47: 924-927
81 Mathis GA, Walls SA, D’Amico P, Gengo TF, Sirica AE. Enzyme profile of rat bile ductular epithelial cells in reference to the resistance phenotype in hepatocarcinogenesis. Hepatology 1989; 9: 477-485
82 Alpini G, Ulrich C, Roberts S, Phillips JO, Ueno Y, Podila PV, Colegio O, LeSage GD, Miller LJ, LaRusso NF. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol 1997; 272: G289-297
83 Martinez-Anso E, Castillo JE, Diez J, Medina JF, Prieto J. Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver. Hepatology 1994; 19: 1400-1406
84 Hofmann AF. Current concepts of biliary secretion. Dig Dis Sci 1989; 34: 16S-20S
85 Lamri Y, Erlinger S, Dumont M, Roda A, Feldmann G. Immunoperoxidase localization of ursodeoxycholic acid in rat biliary epithelial cells. Evidence for a cholehepatic circulation. Liver 1992; 12: 351-354
86 Gurantz D, Hofmann AF. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster. Am J Physiol 1984; 247: G736-748
87 Aldini R, Roda A, Lenzi PL, Ussia G, Vaccari MC, Mazzella G, Festi D, Bazzoli F, Galletti G, Casanova S. Bile acid active and passive ileal transport in the rabbit: effect of luminal stirring. Eur J Clin Invest 1992; 22: 744-750
88 Lazaridis KN, Pham L, Tietz P, Marinelli RA, deGroen PC, Levine S, Dawson PA, LaRusso NF. Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. J Clin Invest 1997; 100: 2714-2721
89 Alpini G, Glaser S, Rodgers R, Phinizy JL, Robertson WE, Lasater J, Caligiuri A, Tretjak Z, LeSage GD. Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes. Gastroenterology 1997; 113: 1734-1740
90 Alpini G, Glaser S, Robertson W, Phinizy JL, Rodgers RE, Caligiuri A, LeSage G. Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes. Am J Physiol 1997; 273: G518-529
91 Francis H, Glaser S, Ueno Y, Venter J, Reichenbach R, Summers R, Alpini G. Novel evidence for the activation of the growth of small (but not large) murine cholangiocytes by Interaction with H1 histamine Receptors. Hepatology 2005; 42: A1145
92 Alpini G, Glaser S, Alvaro D, Ueno Y, Marzioni M, Francis H, Baiocchi L, Stati T, Barbaro B, Phinizy JL, Mauldin J, LeSage G. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Gastroenterology 2002; 123: 1226-1237
93 Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Franchitto A, Onori P, Ueno Y, Marzioni M, Fava G, Venter J, Reichenbach R, Summers R, Alpini G. Administration of r-VEGFA prevents hepatic artery ligation induced bile duct damage in bile duct ligated rats. Am J Physiol 2006; [Epub ahead of print]
94 Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Ueno Y, Meininger CJ, Franchitto A, Onori P, Marzioni M, Taffetani S, Fava G, Stoica G, Venter J, Reichenbach R, De Morrow S, Summers R, and Alpini G. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology 2006; 130:1270-1282
95 Fava G, Glaser S, Phinizy JL, Francis H, Marucci L, Benedetti A, Taffetani S, Venter J, Baumann B, Reichenbach R, Alpini G. Thyroid hormone inhibits cAMP dependent proliferation of cholangiocytes from bile duct ligated rats by a IP3/Ca2+/PKC-dependent mechanism. Hepatology 2003; 38: A1097
96 Glaser S, Katki K, Supowit S, Francis H, Ueno Y, Venter J, Reichenbach R, Dickerson I, Summers R, Chiasson V, DiPette DJ, Alpini G. Alpha-calcitonin gene-related peptide (Alpha-CGRP) stimulates the proliferation of large cholangiocytes during obstructive cholestasis induced by bile duct ligation (BDL) via cAMP-dependent activation of MAPK p38. Hepatology 2005; 42: A13
97 Supowit SC, Zhao H, DiPette DJ. Nerve growth factor enhances calcitonin gene-related peptide expression in the spontaneously hypertensive rat. Hypertension 2001; 37: 728-732
98 Servillo G, Della Fazia MA, Sassone-Corsi P. Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM. Exp Cell Res 2002; 275: 143-154
99 Moriuchi A, Ido A, Nagata Y, Nagata K, Uto H, Hasuike S, Hori T, Hirono S, Hayashi K, Tsubouchi H. A CRE and the region occupied by a protein induced by growth factors contribute to up-regulation of cyclin D1 expression in hepatocytes. Biochem Biophys Res Commun 2003; 300: 415-421
100Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276: 60-66
101Choi EJ, Xia Z, Villacres EC, Storm DR. The regulatory diversity of the mammalian adenylyl cyclases. Curr Opin Cell Biol 1993; 5: 269-273
102Andrisani OM. CREB-mediated transcriptional control. Crit Rev Eukaryot Gene Expr 1999; 9: 19-32
103Alvaro D, Onori P, Metalli VD, Svegliati-Baroni G, Folli F, Franchitto A, Alpini G, Mancino MG, Attili AF, Gaudio E. Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the rat. Hepatology 2002; 36: 297-304
104Seto-Young D, Zajac J, Liu HC, Rosenwaks Z, Poretsky L. The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells. J Clin Endocrinol Metab 2003; 88: 3385-3391
105Clawson GA. Mechanisms of carbon tetrachloride hepatotoxicity. Pathol Immunopathol Res 1989; 8: 104-112
106Lakehal F, Wendum D, Barbu V, Becquemont L, Poupon R, Balladur P, Hannoun L, Ballet F, Beaune PH, Housset C. Phase I and phase II drug-metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium. Hepatology 1999; 30: 1498-1506
107Katayanagi K, Van de Water J, Kenny T, Nakanuma Y, Ansari AA, Coppel R, Gershwin ME. Generation of monoclonal antibodies to murine bile duct epithelial cells: identification of annexin V as a new marker of small intrahepatic bile ducts. Hepatology 1999; 29: 1019-1025
108Diakonova M, Gerke V, Ernst J, Liautard JP, van der Vusse G, Griffiths G. Localization of five annexins in J774 macrophages and on isolated phagosomes. J Cell Sci 1997; 110 (Pt 10): 1199-1213
109Kurosawa H, Que FG, Roberts LR, Fesmier PJ, Gores GJ. Hepatocytes in the bile duct-ligated rat express Bcl-2. Am J Physiol 1997; 272: G1587-1593
110Charlotte F, L’Hermine A, Martin N, Geleyn Y, Nollet M, Gaulard P, Zafrani ES. Immunohistochemical detection of bcl-2 protein in normal and pathological human liver. Am J Pathol 1994; 144: 460-465
111Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O’Dowd BF. Discovery of a novel member of the histamine receptor family. Mol Pharmacol 2001; 59: 427-433
112Dickenson JM. Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1MF-2 smooth muscle cells. Br J Pharmacol 2002; 135: 1967-1976
113Mitsuhashi M, Mitsuhashi T, Payan D. Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells. J Biol Chem 1989; 264: 18356-18362
114Garcia-Sainz JA, Macias-Silva M, Olivares-Reyes A, Romero-Avila MT. Histamine activates phosphorylase and inositol phosphate production in guinea pig hepatocytes. Eur J Pharmacol 1992; 227: 325-331
115Francis H, Taffetani S, Glaser S, Venter J, Phinizy JL, Reichenbach R, Fava G, Alvaro D, Marucci L, Benedetti A, Marzioni M, Alpini G. Histamine stimulates cholangiocyte proliferation through transduction pathways involving the H1 and H2 histamine receptor subtypes. Gastroenterology 2004; 126: AT925
116Francis H, Glaser S, Venter J, Reichenbach R, Fava G, Alpini G. H3/4 histamine receptor agonists inhibit cholangiocyte growth in bile duct ligated (BDL) rats by negative regulation of the cAMP-dependent PKA/ERK1/2 pathway. FASEB J 2005; 19: 480.417
117Francis H, Glaser S, Venter J, Taffetani S, Reichenbach R, Fava G, Marucci L, Benedetti A, Alvaro D, Summers R, Wyndham M, Vaculin S, Alpini G. The specific H3/H4 histamine receptor (HR) agonist, RAMH, inhibits cholangiocyte proliferation in bile duct ligated (BDL) rats by negative regulation of the cAMP- dependent PKA/ERK1/2 pathway. Hepatology 2004; 40: 468
118Hughes K, Antonsson A, Grundstrom T. Calmodulin dependence of NFkappaB activation. FEBS Lett 1998; 441: 132-136
119Lipskaia L, Lompre AM. Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferation. Biol Cell 2004; 96: 55-68
120Glaser S, Francis H, Venter J, Reichenbach R, Ueno Y, Summers R, Alpini G. De novo proliferation of small cholangiocytes requires the activation of the calcium-dependent transcription factor NFATc1/c4. Hepatology 2005; 42: A451
121Cano E, Canellada A, Minami T, Iglesias T, Redondo JM. Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway. J Biol Chem 2005; 280: 29435-29443
122Santini MP, Talora C, Seki T, Bolgan L, Dotto GP. Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation. Proc Natl Acad Sci U S A 2001; 98: 9575-9580
123Marucci L, Alpini G, Glaser SS, Alvaro D, Benedetti A, Francis H, Phinizy JL, Marzioni M, Mauldin J, Venter J, Baumann B, Ugili L, LeSage G. Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 2003; 284: G290-301
124Marzioni M, LeSage GD, Glaser S, Patel T, Marienfeld C, Ueno Y, Francis H, Alvaro D, Tadlock L, Benedetti A, Marucci L, Baiocchi L, Phinizy JL, Alpini G. Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats. Am J Physiol Gastrointest Liver Physiol 2003; 284: G837-852
125Misra S, Ujhazy P, Gatmaitan Z, Varticovski L, Arias IM. The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver. J Biol Chem 1998; 273: 26638-26644
126Marzioni M, Glaser S, Francis H, Taffetani S, Marucci L, Benedetti A, Alvaro D, Phinizy JL, Baumann B, Venter J, Ueno Y, Alpini G. Taurocholate feeding prevents the functional damage of intrahepatic bile ducts induced by adrenergic denervation in a PI3K dependent manner. Hepatology 2003; 38: A28
127Marzioni M, Francis H, Benedetti A, Ueno Y, Fava G, Venter J, Reichenbach R, Mancino MG, Summers R, Alpini G, Glaser S. Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. Am J Pathol 2006; 168:398-409
128Strazzabosco M, Fabris L, Spirli C. Pathophysiology of cholangiopathies. J Clin Gastroenterol 2005; 39: S90-102
129Macdonald P, Palmer J, Kirby JA, Jones DE. Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex. Clin Exp Immunol 2004; 136: 559-567
130Adams DH, Afford SC. Effector mechanisms of nonsuppurative destructive cholangitis in graft-versus-host disease and allograft rejection. Semin Liver Dis 2005; 25: 281-297
131Xu WH, Ye QF, Xia SS. Apoptosis and proliferation of intrahepatic bile duct after ischemia-reperfusion injury. Hepatobiliary Pancreat Dis Int 2004; 3: 428-432
132Nakanuma Y. Necroinflammatory changes in hepatic lobules in primary biliary cirrhosis with less well-defined cholestatic changes. Hum Pathol 1993; 24: 378-383
133Ishibashi H, Shimoda S, Gershwin ME. The immune response to mitochondrial autoantigens. Semin Liver Dis 2005; 25: 337-346
134Bjornsson E, Boberg KM, Cullen S, Fleming K, Clausen OP, Fausa O, Schrumpf E, Chapman RW. Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis. Gut 2002; 51: 731-735
135Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD. Cholangiocarcinoma. Lancet 2005; 366: 1303-1314
136Curry MP, Hegarty JE. The gallbladder and biliary tract in cystic fibrosis. Curr Gastroenterol Rep 2005; 7: 147-153
137Kinnman N, Lindblad A, Housset C, Buentke E, Scheynius A, Strandvik B, Hultcrantz R. Expression of cystic fibrosis transmembrane conductance regulator in liver tissue from patients with cystic fibrosis. Hepatology 2000; 32: 334-340
138Schlenker T, Romac JM, Sharara AI, Roman RM, Kim SJ, LaRusso N, Liddle RA, Fitz JG. Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. Am J Physiol 1997; 273: G1108-1117
139Roman RM, Feranchak AP, Salter KD, Wang Y, Fitz JG. Endogenous ATP release regulates Cl- secretion in cultured human and rat biliary epithelial cells. Am J Physiol 1999; 276: G1391-1400
140Perrone RD, Grubman SA, Murray SL, Lee DW, Alper SL, Jefferson DM. Autosomal dominant polycystic kidney disease decreases anion exchanger activity. Am J Physiol 1997; 272: C1748-1756
141Arima T, Suita S, Shono T, Shono K, Kinugasa Y. The progressive degeneration of interlobular bile ducts in biliary atresia: an ultrastructural study. Fukuoka Igaku Zasshi 1995; 86: 58-64
142Desmet VJ. Vanishing bile duct disorders. Prog Liver Dis 1992; 10: 89-121
143Poupon R, Chazouilleres O, Poupon RE. Chronic cholestatic diseases. J Hepatol 2000; 32: 129-140
144Celli A, Que FG, Gores GJ, LaRusso NF. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. Am J Physiol 1998; 275: G749-757