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This review covers the vertebrate-active retrotransposons and transposons that have been well …

Biology Articles » Biotechnology » Generating and manipulating transgenic animals using transposable elements » Table

Table
- Generating and manipulating transgenic animals using transposable elements

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Table 1:Transposable elements active in vertebrate species for use as gene transfer and insertional mutagenesis vectors.
Transposon
 Familya
 Activity in cultured cellsb
 Activity in vertebrate animalsc
 References
L1
 LINE retrotransposon
 Mouse (PCT) Human (PCT)
 Mouse (TCRG)
 [21,22]
Tol2
 hAT
 Mouse (EP) Human (EP)
 Medaka (TCRG) Zebrafish (TCRG).
 [27,28,32]
Tc1
 Tc1/mariner
 Human (PCT) Mouse (PCT)
 -
 [19,39,40]
Tc3
 Tc1/mariner
 Human (PCT)
 Zebrafish (GT and TCRG)
 [19,42]
Mariner (Himar1)
 Tc1/mariner
 Human (IPT)
 -
 [19,44]
Mariner (Mos1)
 Tc1/mariner
 Human (PCT)
 Chicken (GT), zebrafish (GT)
 [5,19,43]
Minos
 Tc1/mariner
 Human (PCT)
 Mouse (TCRG) Mouse (TCRS)
 [46-48]
Sleeping Beauty
 Tc1/mariner
 Mouse, hamster, human, monkey, dog, cow, sheep, quail, Xenopus, many fish (PCT)
 Mouse (GT) Mouse lung, liver (SCT) Mouse (TCRG) Mouse (TCRS)
 [4,19,30,51,53-56,59,60]
aRelevant superfamily of transposable element. bActivity in immortalized cell lines has been demonstrated using by demonstrating excision from an introduced plasmid (EP), interplasmid transposition (IPT), or full transposition from introduced plasmid (or viral vector) into chromosomes (PCT). cActivity in intact animals (various species) has been demonstrated by germline transgenesis (GT), somatic cell transgenesis (SCT), transposition of chromosomally resident transposon vectors in the germline (TCRG), and transposition of chromosomally resident transposon vectors in the soma (TCRS).
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Source: Reproductive Biology and Endocrinology 2003, 1:80. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.


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