The increasing use of microarray technologies brought about a parallel demand in …

• Abstract
• Background
• Definition of bioentities
• Tests for functional enrichment of bioentities
• Gene set enrichment analysis using bioentities
• A case study of AML
• Conclusions
• Acknowledgements
• References

Biology Articles » Bioinformatics » Functional profiling of microarray experiments using text-mining derived bioentities » A case study of AML

A case study of AML

- Functional profiling of microarray experiments using text-mining derived bioentities

 

A recent study (Stegmaier et al., 2004) described a high-throughput screening methodology to test whether the action of a number of compounds in the transcriptome of cells with acute myeloid leukemia (AML) reproduce the gene signature characteristic of AML differentiation to normal cells. Additional material show different chemical products significantly associated to high expression values. These results should be understood as co-activations of blocks of genes, which have been related to chemical products throughout the biomedical literature, when two experimental conditions are compared (treated AML cells versus different controls). The nature of the chemical products found provide a new perspective on the biochemical processes acting in AML cells with the different treatments received (see Supplementary Material for an explanation).