This collection of zebrafish behavioral mutants provides a novel resource for the …

• Abstract
• Synopsis
• Introduction
• Results
• Discussion
• Materials and Methods
• Supporting Information
• References
• Figures
• Table

1. Benzer S (1973) Genetic dissection of behavior. Sci Am 229: 24–37. 
2. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71–94. 
3. Bargmann CI (1993) Genetic and cellular analysis of behavior in C. elegans. Annu Rev Neurosci 16: 47–71.
4. Zuker CS (1996) The biology of vision of Drosophila. Proc Natl Acad Sci U S A 93: 571–576.
5. Clandinin TR, Lee CH, Herman T, Lee RC, Yang AY, et al. (2001) Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system. Neuron 32: 237–248. 
6. Hardie RC, Raghu P (2001) Visual transduction in Drosophila. Nature 413: 186–193.
7. Chalfie M, Au M (1989) Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Science 243: 1027–1033.
8. Takahashi JS, Pinto LH, Vitaterna MH (1994) Forward and reverse genetic approaches to behavior in the mouse. Science 264: 1724–1733.
9. Neuhauss SC, Biehlmaier O, Seeliger MW, Das T, Kohler K, et al. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J Neurosci 19: 8603–8615. 
10. Balkema GW, Mangini NJ, Pinto LH, Vanable JW Jr. (1984) Visually evoked eye movements in mouse mutants and inbred strains. A screening report. Invest Ophthalmol Vis Sci 25: 795–800.
11. Nicolson T, Rusch A, Friedrich RW, Granato M, Ruppersberg JP, et al. (1998) Genetic analysis of vertebrate sensory hair cell mechanosensation: The zebrafish circler mutants. Neuron 20: 271–283. 
12. Granato M, van Eeden FJ, Schach U, Trowe T, Brand M, et al. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development 123: 399–413. 
13. Nolan PM, Peters J, Vizor L, Strivens M, Washbourne R, et al. (2000) Implementation of a large-scale ENU mutagenesis program: Towards increasing the mouse mutant resource. Mamm Genome 11: 500–506.
14. Brockerhoff SE, Hurley JB, Janssen-Bienhold U, Neuhauss SC, Driever W, et al. (1995) A behavioral screen for isolating zebrafish mutants with visual system defects. Proc Natl Acad Sci U S A 92: 10545–10549.
15. Easter SS Jr., Nicola GN (1996) The development of vision in the zebrafish (Danio rerio). Dev Biol 180: 646–663.
16. Orger MB, Gahtan E, Muto A, Page-McCaw P, Smear MC, et al. (2004) Behavioral screening assays in zebrafish. Methods Cell Biol 77: 53–68.
17. Kay JN, Finger-Baier KC, Roeser T, Staub W, Baier H (2001) Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog. Neuron 30: 725–736.
18. Mullins MC, Hammerschmidt M, Haffter P, Nusslein-Volhard C (1994) Large-scale mutagenesis in the zebrafish: In search of genes controlling development in a vertebrate. Curr Biol 4: 189–202. 
19. Page-McCaw PS, Chung SC, Muto A, Roeser T, Staub W, et al. (2004) Retinal network adaptation to bright light requires tyrosinase. Nat Neurosci 7: 1329–1336.
20. Loosli F, Staub W, Finger-Baier KC, Ober EA, Verkade H, et al. (2003) Loss of eyes in zebrafish caused by mutation of chokh/rx3. EMBO Rep 4: 894–899.
21. Malicki J, Neuhauss SC, Schier AF, Solnica-Krezel L, Stemple DL, et al. (1996) Mutations affecting development of the zebrafish retina. Development 123: 263–273.
22. Goldsmith P, Baier H, Harris WA (2003) Two zebrafish mutants, ebony and ivory, uncover benefits of neighborhood on photoreceptor survival. J Neurobiol 57: 235–245.
23. Wehman AM, Staub W, Meyers JR, Raymond PA, Baier H (2005) Genetic dissection of the zebrafish retinal stem-cell compartment. Dev Biol 281: 53–65. 
24. Brockerhoff SE, Rieke F, Matthews HR, Taylor MR, Kennedy B, et al. (2003) Light stimulates a transducin-independent increase of cytoplasmic Ca²⁺ and suppression of current in cones from the zebrafish mutant nof. J Neurosci 23: 470–480.
25. Hisatomi O, Honkawa H, Imanishi Y, Satoh T, Tokunaga F (1999) Three kinds of guanylate cyclase expressed in medaka photoreceptor cells in both retina and pineal organ. Biochem Biophys Res Commun 255: 216–220.
26. Burrill JD, Easter SS Jr. (1994) Development of the retinofugal projections in the embryonic and larval zebrafish (Brachydanio rerio). J Comp Neurol 346: 583–600.
27. Rick JM, Horschke I, Neuhauss SC (2000) Optokinetic behavior is reversed in achiasmatic mutant zebrafish larvae. Curr Biol 10: 595–598.
28. Xiao T, Roeser T, Staub W, Baier H (2005) A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection. Development 132: 2955–2967.
29. Culverwell J, Karlstrom RO (2002) Making the connection: Retinal axon guidance in the zebrafish. Semin Cell Dev Biol 13: 497–506. 
30. Baier H, Klostermann S, Trowe T, Karlstrom RO, Nusslein-Volhard C, et al. (1996) Genetic dissection of the retinotectal projection. Development 123: 415–425.
31. Driever W, Solnica-Krezel L, Schier AF, Neuhauss SC, Malicki J, et al. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development 123: 37–46. 
32. Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, et al. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio Development 123: 1–36.
33. Chinen A, Hamaoka T, Yamada Y, Kawamura S (2003) Gene duplication and spectral diversification of cone visual pigments of zebrafish. Genetics 163: 663–675.
34. Taylor MR, Van Epps HA, Kennedy MJ, Saari JC, Hurley JB, et al. (2000) Biochemical analysis of phototransduction and visual cycle in zebrafish larvae. Methods Enzymol 316: 536–557.
35. Orger MB, Baier H (2005) Channeling of red and green cone inputs to the zebrafish optomotor response. Vis Neurosci 22: 275–281.
36. Korenbrot JI, Rebrik TI (2002) Tuning outer segment Ca²⁺ homeostasis to phototransduction in rods and cones. Adv Exp Med Biol 514: 179–203.
37. Fain GL, Matthews HR, Cornwall MC, Koutalos Y (2001) Adaptation in vertebrate photoreceptors. Physiol Rev 81: 117–151.
38. Matthews HR (1992) The role of cytoplasmic calcium in photoreceptor light adaptation. J Physiol Paris 86: 147–155.
39. Witkovsky P (2004) Dopamine and retinal function. Doc Ophthalmol 108: 17–40.
40. Rattner A, Sun H, Nathans J (1999) Molecular genetics of human retinal disease. Annu Rev Genet 33: 89–131.
41. Goldsmith P (2004) Zebrafish as a pharmacological tool: The how, why and when. Curr Opin Pharmacol 4: 504–512.
42. Gahtan E, Baier H (2004) Of lasers, mutants, and see-through brains: Functional neuroanatomy in zebrafish. J Neurobiol 59: 147–161.
43. Gahtan E, Tanger P, Baier H (2005) Visual prey capture is controlled by identified reticulospinal neurons downstream of the tectum. J Neurosci 25: 9294–9303.
44. Roeser T, Baier H (2003) Visuomotor behaviors in larval zebrafish after GFP-guided laser ablation of the optic tectum. J Neurosci 23: 3726–3734.
45. Nusslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287: 795–801.
46. Shimoda N, Knapik EW, Ziniti J, Sim C, Yamada E, et al. (1999) Zebrafish genetic map with 2000 microsatellite markers. Genomics 58: 219–232.