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CFD analysis of venous CABG based on in-vivo CT datasets in patients …
Biology Articles » Bioengineering » Flow and wall shear stress in end-to-side and side-to-side anastomosis of venous coronary artery bypass grafts » Conclusion
Our study has investigated the influence of patient specific geometry of end-to-side and side-to-side anastomosis on perianastomotic hemodynamics to identify geometrically driven flow features that might increase the propensity of venous graft failure. CFD analysis allowed us to differentiate hemodynamics in the two types of anastomoses and indicated significant spatial WSS variations especially in the end-to-side anastomosis configuration and an absence of stagnation areas in side-to-side anastomosis. The CFD simulations were performed in only two patients, a fact that limits the significance of our findings, which might differ in patients with different geometry. The numerical method applied herein may provide the basis for future prospective investigations correlating hemodynamic features with neointimal hyperplasia after CABG surgery.
Competing interests The author(s) declare that they have no competing interests. Authors' contributions Guarantor of integrity of entire study: TF Study concepts: TF, BM Study design: TF, EB Literature research: TF, EB, HA Clinical studies: TS, LH, SL Computational studies: TF, EB, DP Data acquisition: LH, SL Data analysis/interpretation: TF, EB, HA Statistical analysis: TF, EB Manuscript preparation: TF, EB Manuscript editing: TF, EB HA, DP, BM Manuscript revision/review: TF, EB, HA, DP, BM All authors read and approved the final version of the manuscript. Acknowledgements Supported by the National Center of Competence in Research, Computer Aided and Image Guided Medical Interventions (NCCR-CO ME) of the Swiss National Science Foundation.
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