The article reviews the fibroblasts on normal adult human skin wherein at …

• Summary
• Introduction
• Papillary and reticular dermal fibroblasts
• Extracellular matrix differences
• Fibroblasts and basement membrane formation
• Intercellular communication and interfollicular dermal fibroblasts
• Dermal fibroblastic cells are associated with hair follicles
• The fibroblast in cutaneous wound repair
• The dermal fibroblast in bioengineering
• Dermal and skin equivalents as biological models
• Dermal and skin equivalents for skin replacement
• Concluding remarks
• Acknowledgments
• References
• Figures
• Tables

We gratefully acknowledge Irwin Schafer (Case Western ReserveUniversity) and Daniel Asselineau and Hervé Pageon (L'OréalLife Sciences, Clichy, France) for providing the adult site-matcheddermal fibroblasts used in experimental studies in this laboratory,and David Carrino and Marilyn Baber for expert advice and creativecollaboration. Financial support for studies in this laboratorywas provided by L'Oréal Life Sciences and the NationalInstitutes of Health.