Login

Join for Free!
119317 members
table of contents table of contents

Biology Articles » Evolutionary Biology » Failure of anti-tumor immunity inmammals - evolution of the hypothesis

Abstract
- Failure of anti-tumor immunity inmammals - evolution of the hypothesis

Failure of anti-tumor immunity inmammals - evolution of the hypothesis

I. Bubanovic1 and S. Najman2

1Department of Obstetrics and Gynecology, "Medica Center", Nis, Novosadska 1/c, Nis, Serbia and Montenegro.
2Institute for Biology, University Medical School, Nis, Serbia and Montenegro.

Abstract

Observations on the morphological and functional similarity between embryonic or trophoblast tissues and tumors are very old. Over a period of time many investigators have created different hypotheses on the origin of cancerogenesis or tumor efficiency in relation to the host immune system. Some of these ideas have been rejected but many of them are still current. A presumption of the inefficiency of anti-tumor immunity in mammals due to the high similarity between trophoblast and embryonic cells to tumor cells is very real. The mechanisms for the escape of tumors from the immune response are very similar to the mechanisms for the escape of a fetoplacental unit from the maternal immune response. The similarity between these two mechanisms is so great that any randomness must be banished. At the same time, an incidence of malignant tumors and the types of more frequent tumors in non-mammalian vertebrates is significantly different to that in mammals. Lastly, the mechanisms of anti-tumor immunity in mammals are substantially different from the mechanisms of anti-tumor immunity in other classes of vertebrates. These facts indicate that the immune system of mammals during anti-tumor immune response is tricked by the similarity between tumor cells and trophoblast or other placental cells. From this aspect, our conclusion is that anti-tumor immunity failure in mammals can be defined as an immunoreproductive phenomenon, which is developed under the evolutionary pressure of autoimmunity and reproductive effectiveness.

Key Words: Anti-tumor immunity, mammals, vertebrates, pregnancy, trophoblast.

 

-------------------------

Note:
[An article from Ivan Bubanovic (author)]

rating: 5.00 from 4 votes | updated on: 16 Feb 2009 | views: 5759 |

Rate article:







excellent!bad…