Epigenetic Microenvironment Awakes Genes
S.Krupanidhi[V1] , S.Sai Madhukar* and Y R Ahuja**
Department of Biosciences, Sri Sathya Sai University, Prasanthi Nilayam 515 134 A P, India , *Department of Bioinformatics, Sathyabhama University, Old Mahabilam Road, Chennai, 600 019 T N, India, ** Dept. of Genetics and Molecular Medicines, Vasavi Medical and Research Centre, 6-1-91 Kharaitabad, Hyderabad 500 004
Article submitted on June 27, 2008.
Article published on July 18, 2008
An article submitted by S.Krupanidhi, (18 July 2008): Epigenetic Microenvironment Awakes Genes. Published by Biology-Online.org.
The field of epigenetics is an emerging area. It aims to strengthen the genome based therapeutics. The reviewing of literature indicates that despite the invariant nature of genomic DNA, the epigenetic microenvironment dictates tissues’ specificity. Mendel’s concept of alleles and the newer concept of epialleles and epimutations which are in vogue in the genomic era are vividly elaborated. The role of epigenetics in the reprogramming and maintaining stable methylated states of CpG islands during growth and differentiation are reviewed. Epigenetic regulation of imprinted genes and tumor suppressor genes towards gene imprinting and silencing and their transgenerational phenotypes and therapeutic avenues respectively have generated impetus to unfold methylation maps through yet another mammoth and forthcoming Human Epigenome Project.
Key Words: Epigenetics, Microenvironment, Cellular differentiation, Epialleles, Imprinted genes, DNA methylation, Histone deacetylation, Cancer and Human Epigenome Project.