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The family Enterobacteriaceae includes a variety of pathogens that pose significant threats to human health directly, and indirectly through agricultural crops and livestock. The Enteropathogen Resource Integration Center (ERIC, www.ericbrc.org) is one of the eight Bioinformatics Resource Centers (BRC) for Biodefense and Emerging/Re-Emerging Infectious Diseases (http://www.brc-central.org/). Funded by the National Institute of Allergy and Infectious Diseases (NIAID), ERIC serves as an information resource for enterobacteria on the NIAID established list of select agents related to biodefenseādiarrheagenic Escherichia coli, Shigella spp., Salmonella spp., Yersinia enterocolitica and Yersinia pestis. ERIC seeks to support basic research on pathogenesis and development of novel vaccines, therapeutics and diagnostics for these organisms by:
- Adding value to genome data through manual and automated curation with particular focus on biological subsystems relevant to pathogenicity.
- Integrating diverse sources of data ranging from publications on individual genes to large-scale proteomics data sets.
- Developing tools for analyzing and visualizing these data.
- Offering training and specialized analyses to the research community.