Fortunately, all of the patients cooperated well and did not show any adverse effect of these herbal drugs.
Changes of lipid profiles after 6 weeks and results of paired t test are shown in table 2 and 3, respectively. It was found that changes in triglyceride, total cholesterol, LDL-cholesterol, and HDL-cholesterol were significantly different between three groups.
Placebo could not improve lipid profile. Triglyceride, total cholesterol, and LDL-cholesterol increased and HDL-cholesterol was reduced. These changes were not meaningful (P-value > 0.05).
Anethum didn't have any beneficial effect on triglyceride (6.0% increase) and HDL-cholesterol (3.1% reduction). It could reduce total cholesterol by 0.4 % and LDL-cholesterol by 6.3 %, but these reductions were not significant statistically (P-value: .828, .210, respectively).
At the end of the six-week intervention period, it was fond that changes in triglyceride, total cholesterol, LDL-cholesterol, and HDL-cholesterol were significantly different from other groups. The mean total cholesterol concentration dropped in the garlic group by 26.82 mg/dl (P-value: .000.) Similarly, LDL-cholesterol was reduced in this group by 22.18 mg/dl (P-value: .000). Surprisingly, HDL-cholesterol was increased by 10.02 mg/dl (P-value: .000). Although triglyceride dropped by 13.72 mg/dl but this was not meaningful (P-value: .222).