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Anethum has no significant effect on lipid profile, but garlic tablet has …


Biology Articles » Biochemistry » Lipid Biochemistry » Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients » Discussion

Discussion
- Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients

Garlic

Our study suggests that garlic reduces total cholesterol & LDL-cholesterol. This is similar to Alder and Holub's study (11.5% decrease of total cholesterol, and 14.2% decrease of LDL-cholesterol) [31], Tohidi and Rahbani's trial (9.0% decrease of total cholesterol, 15.0% decrease of LDL-cholesterol)[32], study of Steiner et al (6.1% decrease of total cholesterol, 4.0% decrease of LDL-cholesterol) [18]. Also, other studies explained these benefits [24,25].

HDL-cholesterol should be investigated in more clinical trials. Stevinson et al [33] in meta-analysis of randomized clinical trials on antihyperlipidemic effect of garlic explained that a slight increase in HDL-cholesterol level in the garlic group was not significantly different from the effect of placebo. Our search could corroborate garlic effect on increasing HDL-cholesterol (P-value: .000, HDL-cholesterol increased by 15.7%)

Triglyceride dropped by prescription of garlic tablet by 6.3% (13.72 mg/dl), according to Tohidi and Rahbani's study [32], and Mader's trial [34]. But due to P-value: .222, this reduction was not significant difference from the effect of placebo.

Anethum graveolens

Anethum could reduce total cholesterol and LDL-cholesterol (1.12 mg/dl and 9.34 mg/dl, respectively) but these differences were not significant (P-value: .828 and .210, respectively). Surprisingly, it reduced HDL-cholesterol (3.1%) and increased triglyceride level by 6.0%. Our study on anethum is opposite to that of Yazdanparast and Alavi [34].

In conclusion we found that enteric-coated garlic tablet can reduce total cholesterol, LDL-cholesterol and increase HDL-cholesterol, with no effect on triglyceride. On the other hand, anethum graveolens can not be an antihyperlipidemic agent.


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