A comprehensive review of published Markov models in depression and identified potential …

• Abstract
• Background
• Key clinical features of unipolar depression
• Application
• Discussion
• Conclusion
• References
• Figures

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Figure 1. Diagram of the five possible outcomes across the three phases of treatment of depression (Source: Thase M.E., 2000). Acute phase: usually 2 to 3 months; Continuation phase: usually 4 to 6 months; Maintenance phase: can last up to 5 years (Definitions from Kupfer et al. study, 1992)

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Figure 2. Key risk factors for recurrent depression

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Figure 3. Cumulative probability of relapse after remission from depressive symptoms given the number of prior depression events (Source: Solomon et al., 2000).

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Figure 4. Cumulative probability of remission from index episode of depression (Source: Keller et al., 1998).

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Figure 5. Markov model synthetic representation. Cycle length: 1 week. Circles represent health states. Dotted circles represent temporary health states. Arrows represent transition probabilities: 1: Weekly probabilities of remission, according to time spent with the illness. 2: Weekly probabilities of relapse according to patient's risk profile.

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Figure 6. Discrete Event Simulation algorithm.

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