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To directly radiolabel an anti-hepatoma mAb fragment HAb18 F(ab’)2 with 99mTc …


Biology Articles » Biophysics » Medical Biophysics » Direct technetium-99m labeling of anti-hepatoma monoclonal antibody fragment: a radioimmunoconjugate for hepatocellular carcinoma imaging » Table 2

Table 2
- Direct technetium-99m labeling of anti-hepatoma monoclonal antibody fragment: a radioimmunoconjugate for hepatocellular carcinoma imaging

Table 2 Biodistribution of 99mTc-HAb 18F(ab’)2 in nude mice bearing hepatoma (x-±s, %ID/g)

 

Organ

Time after injection (h)

4

10

24

Blood

2.21±0.24

1.45±0.15

0.56±0.09

Kidney

72.38±14.37

70.47±15.23

56.45±11.36

Liver

1.82±0.48

1.59±0.31

1.43±0.27

Lung

1.62±0.34

1.40±0.17

0.75±0.21

Stomach

1.37±0.39

1.05±0.28

0.50±0.29

Spleen

2.35±0.81

2.11±0.75

1.82±0.85

Large intestine

1.16±0.34

1.42±0.39

0.94±0.32

Small intestine

0.97±0.31

0.95±0.18

0.62±0.24

Heart

2.04±0.55

1.83±0.48

1.17±0.42

Muscle

1.15±0.20

0.77±0.28

0.51±0.25

Brain

0.18±0.02

0.07±0.04

0.02±0.01

Tumor

5.14±2.26

5.84±2.98

6.57±3.01


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