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To directly radiolabel an anti-hepatoma mAb fragment HAb18 F(ab’)2 with 99mTc …


Biology Articles » Biophysics » Medical Biophysics » Direct technetium-99m labeling of anti-hepatoma monoclonal antibody fragment: a radioimmunoconjugate for hepatocellular carcinoma imaging » Table 1

Table 1
- Direct technetium-99m labeling of anti-hepatoma monoclonal antibody fragment: a radioimmunoconjugate for hepatocellular carcinoma imaging

Table 1 Effect of molar ratio (Sn/GH: mAb) on quantity of-SH, fre e 99mTcO4- and colloid and labeling efficiency (%, n=3)

 

Molar ratio(Sn/GH: mAb)

SH groups/mAb

99mTcO4-

colloid

labeling efficiency

Control

0±0

62.1±4.5

1.1±1.2

2.0±0.9

101

0.43±0.04

3.0±1.4

1.4±1.1

44.6±3.8

201

1.25±0.10

2.9±1.1

1.4±0.7

72.8±5.1

301

2.46±0.08

2.0±0.9

3.2±1.4

78.6±3.2

401

3.34±0.09

1.8±1.2

2.8±1.3

84.2±2.8

501

3.61±0.12

2.1±0.8

3.6±1.5

84.4±3.4


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